Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression

Current insights into the regulation of programmed cell death by NF-κB

“…This was elegantly demonstrated in different mouse models of inflammationassociated cancer ( Figure 1; Greten et al, 2004;Pikarsky et al, 2004;reviewed in de Visser and Coussens, 2005;Fan et al, 2006a; and the review by Basseres and Baldwin, 2006). While inhibition of NF-kB activity via targeted inactivation of IKKb in intestinal epithelial cells dramatically reduces tumor incidence in a mouse model of colitis-associated cancer owing to increased apoptosis, its inactivation in myeloid cells also reduces tumor incidence, but in this case by interfering with tumor cell growth in a paracrine fashion, owing to reduced production of proinflammatory cytokines .…”

“…How NF-jB's role in apoptosis and inflammation impacts its role in cancer: new insights As described in greater detail in the accompanying review from Basseres and Baldwin (2006), NF-kB is a key contributing factor to the pathogenesis of many human tumors and their chemoresistance (reviewed in Rayet and Ge´linas, 1999;Baldwin, 2001;. A few examples include classical Hodgkin's lymphoma (cHL), multiple myeloma (MM), primary mediastinal B-cell lymphoma (PMBL), therapy-resistant diffuse large B-cell lymphoma (DLBCL), childhood acute lymphoblastic leukemia (c-ALL) and breast, prostate, ovarian, lung, colon and renal cell carcinoma (Bargou et al, 1997;Nakshatri et al, 1997;Sovak et al, 1997;Alizadeh et al, 2000;Cogswell et al, 2000;Kordes et al, 2000;Davis et al, 2001;Hinz et al, 2001;Kalaitzidis et al, 2002;Shipp et al, 2002;Munzert et al, 2004).…”

α-Catulin, a Rho signalling component, can regulate NF-κB through binding to IKK-β, and confers resistance to apoptosis

“…There is ample evidence that both the NF-kB and RhoA signalling pathways play multiple roles in tumorigenesis, of which cell migration, invasion and escape from apoptosis are important aspects (Schmitz et al, 2000;Basseres and Baldwin, 2006). The finding that a-catulin comprises a part of these two signalling pathways and influences their respective cellular functions is therefore of considerable interest.…”

Inhibitors of NF-κB signaling: 785 and counting

“…For example, NF-kB complexes are known to play key roles in the inflammatory response, in the inhibition of apoptosis, and in cell proliferation, and as a consequence, mis-regulated, usually sustained, NF-kB activity also contributes to human disease states, including most chronic inflammatory diseases and many cancers (Pahl, 1999;Basse`res and Baldwin, 2006;Dutta et al, 2006;Hayden et al, 2006). Therefore, the identification of specific and potent inhibitors of NF-kB has been the goal of many researchers and pharmaceutical companies.…”