Nuclear Hmgb1

Raucci, Angela; Capogrossi, Maurizio C.

doi:10.1016/j.jacbts.2019.03.008

Cited by 4 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was shown that cytosolic HMGB1 binding TLR9 improves tissue repair, increased wound healing, and angiogenesis [ 88 ]. Raucci and colleagues [ 89 ] showed that protective or harmful effects of HMGB1 and TLR9 might finally dependent on the concentration of HMGB1. Hence, future studies are required to understand the detailed interaction of DNA-binding proteins to cfDNA and their impact on the resulting immunological function after tissue injury.…”

Section: Immune Sensing Of Cfdnamentioning

confidence: 99%

The role of circulating cell-free DNA as an inflammatory mediator after stroke

2023

View full text Add to dashboard Cite

Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex role of the immune system in the pathophysiology of stroke. Ischemic brain injury leads to the release of cell-free DNA, a damage-associated molecular pattern, which binds to pattern recognition receptors on immune cells such as toll-like receptors and cytosolic inflammasome sensors. The downstream signaling cascade then induces a rapid inflammatory response. In this review, we are highlighting the characteristics of cell-free DNA and how these can affect a local as well as a systemic response after stroke. For this purpose, we screened literature on clinical studies investigating cell-free DNA concentration and properties after brain ischemia. We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.

show abstract

Section: Immune Sensing Of Cfdnamentioning

confidence: 99%