Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity

Kundra, Ajay; Andrei, Mirela; Westra, William H.; Chaudhry, Rashid; Moussouris, Harry F.; Gohari, Arash; Wang, Jen C.

doi:10.1002/hed.24418

Cited by 11 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 Due to the availability of the antibody to NUT, a protein which is normally exclusive to the testes and diagnostic of NMC for outside F I G U R E 3 (A) Program of intensity-modulated radiation therapy; (B) Neck magnetic resonance imaging examination 15 mo after vocal cord resected expression, the diagnosis of NMC is more convenient and frequent. 14 However, the laryngeal NMC is still extremely rare with only seven cases reported till now, 3,6 and we added one new case of our own. There were four males and four females and the mean age of diagnosis is 26.6 years (Table 1), which is in accordance with the young age (avg.…”

Section: Discussionmentioning

confidence: 69%

“…However, the laryngeal NMC is still extremely rare with only seven cases reported till now, and we added one new case of our own. There were four males and four females and the mean age of diagnosis is 26.6 years (Table ), which is in accordance with the young age (avg.…”

Section: Discussionmentioning

confidence: 99%

“…NUT midline carcinoma that arises in the larynx is extremely rare, with only seven cases reported thus far. All the seven cases presented at an extensive clinical stage and showed a poor prognosis with the survival time ranged from 3 to 11 months …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Successful treatment of a case with NUT midline carcinoma in the larynx and review of the literature

Zhang¹,

Liu²,

Zhang

et al. 2019

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Successful treatment of a case with NUT midline carcinoma in the larynx and review of the literature

Zhang¹,

Liu²,

Zhang

et al. 2019

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…Since initial report in 1991, total 105 cases were described. 5,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The sinonasal tract accounted for 73.4% of initial presenting site and followed by salivary gland (11%), larynx (7.3%), pharynx (4,6%), and oral cavity (3.7%) ( Table 3). Regarding the overall frequency of NUT carcinoma in head and neck, previous studies reported different results according to the study subjects (1.9-17.9%).…”

Section: Frequency and Distribution Of Nc With Review Of Literaturementioning

confidence: 99%

Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review

et al. 2020

View full text Add to dashboard Cite

Background: Nuclear protein in testis (NUT) carcinoma is a poorly differentiated carcinoma defined by the presence of NUT gene rearrangement. In the head and neck, the true prevalence of NUT carcinoma is unknown. Methods:We retrospectively investigated NUT expression with clinicopathologic features in 362 patients of poorly differentiated or undifferentiated carcinomas in the head and neck, and reviewed the literature reports.Results: Four (4/362, 1.1%) cases showed strong nuclear expression for NUTspecific monoclonal antibody, and all these tumors were in the sinonasal tract (4/40, 10%). The clinical outcome and histology were diverse unlike previously described. Although previous studies reported different frequency results according to study subjects, frequencies in sinonasal tract are relatively constant (10/80, 12.5%).

show abstract

“…The encoded oncoprotein BRD4–NUT contributes to carcinogenesis by blocking epithelial cell differentiation and drives growth of the NMC cells . Although recognized only recently, a series of publications since 2001 have established the concept of NUT NMC as a distinct entity …”

Section: Introductionmentioning

confidence: 99%

NUT midline carcinoma of the larynx: an international series and review of the literature

et al. 2017

View full text Add to dashboard Cite

Aims NUT midline carcinoma (NMC) is a rare undifferentiated and aggressive carcinoma that characteristically locates to the midline of the head and neck, and mediastinum. NMC is characterised by chromosomal rearrangements of the gene encoding nuclear protein in testis, NUT, at 15q14. The BRD4 gene on 19q13 is the most common translocation partner forming a fusion oncogene, BRD4-NUT. By the end of 2014, the International NUT Midline Carcinoma Registry had 48 patients treated for NMC. Laryngeal NMC are exceedingly rare and we report a case series of seven cases. Material and Methods We searched for cases in files of different hospitals as well as a thorough search of the English literature. The diagnosis of NMC is made by demonstration of NUT rearrangement either by immunohistochemistry, FISH or RT-PCR. We found three previously published cases and add in this series four cases of our own. Conclusions NMC consists of monomorphic, often discohesive, cells with an epithelioid appearance and distinct nucleoli. The tumours typically show abrupt squamous differentiation. The mean age of the patients was 34 years, hence significantly lower than that for conventional laryngeal carcinoma. All tumours were located in the supraglottis and five patients died of the disease after 3, 7, 8, 9 and 11 months. Laryngeal NMC may be underdiagnosed and an increased awareness amongst pathologists is warranted. NMC has characteristic morphological features and positive immunostaining with the NUT antibody is diagnostic. Its aggressive behaviour demands a very intense treatment strategy and the need for its recognition is further emphasised by new promising treatment strategies.

show abstract

Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity

Cited by 11 publications

References 16 publications

Successful treatment of a case with NUT midline carcinoma in the larynx and review of the literature

Successful treatment of a case with NUT midline carcinoma in the larynx and review of the literature

Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review

NUT midline carcinoma of the larynx: an international series and review of the literature

Contact Info

Product

Resources

About