Nuclear protein of the testis midline carcinoma in the oral cavity: retrospective review of those initially diagnosed as poorly differentiated squamous cell carcinoma using an anti-C52B1 antibody

Aizawa, Hitoshi; Yamada, Shin‐ichi; Sakai, Hironori; Otakiri, H.; Akita, Daisuke; Gibo, Takahiko; Kitamura, Hiroshi

doi:10.1016/j.ijom.2019.02.012

Cited by 5 publications

(14 citation statements)

References 18 publications

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“…12,24,25 NUT carcinomas often affect the chest and head and neck region. Our results support previous findings, 13,31 which indicate that the diagnosis of NUT carcinoma should be considered especially when assessing poorly differentiated SCC or undifferentiated carcinoma on histomorphological analysis. 11,12,[26][27][28] To date, the most comprehensive reviews involved 63 NUT carcinomas establishing a clinical database, 29 as well as a meta-analysis of 32 NUT carcinomas.…”

Section: Discussionsupporting

confidence: 92%

“…13 These cases were identified after assessing 27 oral cases previously diagnosed as poorly differentiated SCC. In fact, recently, two cases in the oral cavity have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…4 SDSCs are characterized by presenting a basaloid, plasmacytoid/rhabdoid, [1][2][3] or oncocytoid/ adenocarcinoma-like 4 histopathological pattern. 13 Notably, the diagnosis of NUT carcinoma can be established by immunohistochemistry, which shows uniform typical nuclear positivity. 6 These findings indicate that the histomorphological spectrum of SMARCB1 (INI-1)-deficient tumors are broader than initially described.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, 12 SMARCB1 (INI-1)-deficient sinonasal adenocarcinomas have been reported. [11][12][13] Initially described in children and adolescents, it is now clear that NUT carcinoma can develop in all ages, without gender distinction, although its true incidence remains unclear. Moreover, we have recently reported a rare case of SMARCB1 (INI-1)intact myoepithelial carcinoma with rhabdoid features in the maxillary sinus, expanding the clinicopathological spectrum of sinonasal carcinomas.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, we have recently reported a rare case of SMARCB1 (INI-1)intact myoepithelial carcinoma with rhabdoid features in the maxillary sinus, expanding the clinicopathological spectrum of sinonasal carcinomas. 2,6,[11][12][13][14] In this context, the correct diagnosis of these cases is fundamental. 1,[8][9][10] Nuclear protein in testis (NUT) carcinoma is a rare and aggressive poorly differentiated carcinoma, often affecting the head and neck region (especially the nasal cavity and paranasal sinuses).…”

Section: Introductionmentioning

confidence: 99%

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SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

et al. 2019

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Background: SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively.Methods: Through SMARCB1 (INI-1) and NUT immunomarkers, 643 head and neck carcinomas were assessed retrospectively. Moreover, SMARCB1(INI-1)-deficient and NUT carcinomas were additionally evaluated by immunohistochemistry, as well as in situ hybridization analysis for HPV and EBV.Results: Four SMARCB1 (INI-1)-deficient carcinomas (located in lower lip, soft palate, hypopharynx and vocal cord, this latter high-risk HPV positive) and three NUT carcinomas (all located in oropharynx) were detected, previously diagnosed as nonkeratinizing or moderately differentiated squamous cell carcinoma. All cases showed squamous differentiation. NUT carcinomas than SMARCB1 (INI-1)-deficient carcinomas showed low overall survival rate. Conclusion: The current cases expand the clinicopathological spectrum of SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas. Notably, the diagnosis of these cases is easily reached through immunohistochemistry, with impact on their accurate classification, treatment, and prognosis. K E Y W O R D Shead and neck squamous cell carcinoma, immunohistochemistry, in situ hybridization, NUT midline carcinoma, SMARCB1 (INI-1)-deficient carcinoma

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Section: Discussionsupporting

confidence: 92%

“…13 These cases were identified after assessing 27 oral cases previously diagnosed as poorly differentiated SCC. In fact, recently, two cases in the oral cavity have been reported.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

et al. 2019

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Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review

et al. 2020

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Background: Nuclear protein in testis (NUT) carcinoma is a poorly differentiated carcinoma defined by the presence of NUT gene rearrangement. In the head and neck, the true prevalence of NUT carcinoma is unknown. Methods:We retrospectively investigated NUT expression with clinicopathologic features in 362 patients of poorly differentiated or undifferentiated carcinomas in the head and neck, and reviewed the literature reports.Results: Four (4/362, 1.1%) cases showed strong nuclear expression for NUTspecific monoclonal antibody, and all these tumors were in the sinonasal tract (4/40, 10%). The clinical outcome and histology were diverse unlike previously described. Although previous studies reported different frequency results according to study subjects, frequencies in sinonasal tract are relatively constant (10/80, 12.5%).

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Large cell neuroendocrine carcinoma on the floor of the mouth: a rare entity in an unusual location

Martínez

Cuéllar

Urmeneta

et al. 2022

International Journal of Oral and Maxillofacial Surgery

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Nuclear protein of the testis midline carcinoma in the oral cavity: retrospective review of those initially diagnosed as poorly differentiated squamous cell carcinoma using an anti-C52B1 antibody

Cited by 5 publications

References 18 publications

SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review

Large cell neuroendocrine carcinoma on the floor of the mouth: a rare entity in an unusual location

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