Nuclear Receptor Coactivator 5 is Correlated with Progression in Breast Carcinoma

Xia, Erjie; Hu, Wenjing; Bhandari, Adheesh; Sindan, Namita; Huang, Du-Ping

doi:10.2174/1871520621666210126093630

Cited by 3 publications

(3 citation statements)

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“…As a regulator of IL-6, NCOA5 is thought to be related to inflammation. The expression of NCOA5 in breast cancer tissues was significantly higher than that in normal tissues, and the high expression of NCOA5 was associated with a decreased overall survival in breast cancer patients (Xia et al, 2021;Ye et al, 2017). Ye et al (2017) found that the high NCOA5 expression, old age (>60) and HER-2 expression were three independent high risk factors in luminal breast cancer.…”

Section: Ncoa5 and Breast Cancermentioning

confidence: 99%

“…Ye et al (2017) found that the high NCOA5 expression, old age (>60) and HER-2 expression were three independent high risk factors in luminal breast cancer. Moreover, the high NCOA5 expression alone is also an independent risk factor in HER-2 positive breast cancer patients (Xia et al, 2021). Under the action of E2, NCOA5, as a co-activator of ERα, can be recruited to RORA promoter to promote the transcriptional activation of RORA (Sarachana and Hu, 2013).…”

Section: Ncoa5 and Breast Cancermentioning

confidence: 99%

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Co-regulator NCOA5 and cancer

Chen¹,

Cui²,

Guo³

et al. 2022

Biocell

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NCOA5 encodes a co-regulator for estrogen receptors (ERα and ERβ), orphan nuclear receptors (REV-ERBα and REV-ERBβ) and liver X receptor. It can influence many cellular processes by either promoting or inhibiting gene expression through its two important functional motifs: LxxLL (co-activator) and ΦxxΦΦ (co-repressor). Many reports have revealed the important roles of NCOA5 in diseases, such as diabetes, reproductive defects and autoimmune disease. In this review, we focus on its function in cancers and summary the current research progresses regarding its different roles in various cancers.

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Section: Ncoa5 and Breast Cancermentioning

confidence: 99%

Section: Ncoa5 and Breast Cancermentioning

confidence: 99%

Co-regulator NCOA5 and cancer

Chen¹,

Cui²,

Guo³

et al. 2022

Biocell

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show abstract

“…Moreover, it has been verified that NCOA5 is highly expressed in breast cancer tissues, and is lowly expressed in adjacent non-cancerous tissues, and NCOA5 is highly associated with the poor prognosis of breast cancer patients ( 8 ). Furthermore, NCOA5 was greatly correlated with lymph node metastasis in breast cancer, and its expression could predict the overall survival time, thus NCOA5 is considered as a promising novel management target for breast cancer ( 9 ), whereas its specific regulatory mechanism in the progression of breast cancer has not been fully elucidated till now.…”

Section: Introductionmentioning

confidence: 99%

Role of the TPX2/NCOA5 axis in regulating proliferation, migration, invasion and angiogenesis of breast cancer cells

Zhang

2023

Exp Ther Med

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Breast cancer is a common malignant tumor in women. Increasing evidence has demonstrated that nuclear receptor coactivator 5 (NCOA5) and targeting protein for xenopus kinesin-like protein 2 (TPX2) serve vital roles in the progression of breast cancer. However, to the best of our knowledge, the molecular mechanisms underlying the involvement of TPX2/NCOA5 in the development of breast cancer are not fully understood at present. In the present study, the expression levels of NCOA5 and TPX2 were compared between paired non-tumor and tumor tissues of patients with breast cancer using the TNMplot tool. Expression differences of NCOA5 and TPX2 in human breast epithelial cell lines (MCF10A and MCF12A) and human breast cancer cell lines (MCF7 and T47D) were assessed via reverse transcription-quantitative PCR and western blotting. Additionally, proliferation, migration and invasion of breast cancer cells were determined via Cell Counting Kit-8, would healing and transwell assays. In vitro angiogenesis was determined using a tube formation assay. Furthermore, TPX2 was identified as a high-confidence NCOA5 interactor based on BioPlex network data sets. A co-immunoprecipitation assay was adopted to confirm the interaction between TPX2 and NCOA5. The present study revealed that TPX2 and NCOA5 were highly expressed in breast cancer cells. TPX2 interacted with NCOA5 and there was a positive association between TPX2 and NCOA5 expression. NOCA5 knockdown repressed the proliferation, migration, invasion and in vitro angiogenesis of breast cancer cells. In addition, TPX2 knockdown suppressed the proliferation, migration and invasion of breast cancer cells, and inhibited in vitro angiogenesis, and all of these effects were reversed following NCOA5 overexpression. In conclusion, NCOA5 was a downstream target of TPX2 in enhancing proliferation, migration, invasion and angiogenesis of breast cancer cells.

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Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5

Li,

Cui,

et al. 2024

Front. Oncol.

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BackgroundLaryngeal cancer is a common head and neck cancer, and its occurrence and development are closely related to a variety of epigenetic modifications. protein arginine methyltransferase 1 (PRMT1) is an important type I protein arginine methyltransferase, which catalyzes the monomethylation and asymmetric dimethylation of arginine and participates in the occurrence and development of a variety of cancers. Current research has found that the expression of PRMT1 is increased in laryngeal carcinoma tissues. Histone modifications play a key role in regulating gene expression and maintaining cellular function. In particular, histone H4 arginine 3 dimethylation (H4R3me2a) has been shown to be associated with the development of a variety of cancers. Nuclear Receptor Coactivator 5 (NCOA5) is an important nuclear receptor coactivator, which regulates gene expression through the interaction between various nuclear receptors and other transcription factors. The present study aimed to investigate how PRMT1-mediated H4R3me2a methylation affects the proliferation, migration and invasion of laryngeal cancer cells and to verify the role of NCOA5 in this process.MethodsThe expression of PRMT1 and NCOA5 was inhibited by siRNA mediated gene knockdown in laryngeal cancer cells. The changes of H4R3me2a protein levels were detected by Western Blotting, and cell proliferation, migration and invasion abilities were evaluated by CCK-8, cell scratch assay, Transwell migration and invasion assay. RT-qPCR was used to detect the mRNA expression levels of related genes. The overexpression experiment of NCOA5 was carried out by constructing overexpression vector to verify its effect.ResultsAfter PRMT1 knockdown, the expression of H4R3me2a in laryngeal cancer cells was significantly decreased, and the cell proliferation, migration and invasion abilities were weakened. Similarly, knockdown of NCOA5 expression also resulted in decreased H4R3me2a levels and attenuated cell proliferation, migration and invasion. Overexpression of NCOA5 partially restored H4R3me2a levels and cell proliferation, migration and invasion abilities.

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Nuclear Receptor Coactivator 5 is Correlated with Progression in Breast Carcinoma

Cited by 3 publications

References 0 publications

Co-regulator NCOA5 and cancer

Co-regulator NCOA5 and cancer

Role of the TPX2/NCOA5 axis in regulating proliferation, migration, invasion and angiogenesis of breast cancer cells

Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5

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