Nuclear Receptors<i>Nur77</i>and<i>Nurr1</i>Modulate Mesenchymal Stromal Cell Migration

Maijenburg, Marijke W.; Gilissen, Christian; Melief, Sara M.; Kleijer, Marion; Weijer, Kees; Brinke, Anja ten; Roelofs, Helene; Tiel, Claudia M. van; Veltman, Joris A.; Vries, Carlie J.M. de; Schoot, C. Ellen van der; Voermans, Carlijn

doi:10.1089/scd.2011.0076

Cited by 55 publications

(42 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nurr1 is also a key target gene of thromboxane A2 receptor-signaling pathway and is critical for the proliferation of lung carcinoma cells by regulating cyclin D1 expression (Li and Tai, 2009). There is also study showing that Nurr1 is upregulated in migratory mesenchymal stromal cells (MSC), and overexpression of Nurr1 in nonmigratory fetal bone marrow MSC (FBMSC) significantly increases migration compared with mock-transduced cells (Maijenburg et al, 2012). The above studies further support oncogenic role for Nurr1 in promoting the cancer development.…”

Section: 2023 Orphan Nuclear Receptor Nurr1 Is a Novel Potential Marmentioning

confidence: 67%

See 1 more Smart Citation

Orphan Nuclear Receptor Nurr1 as a Potential Novel Marker for Progression in Human Prostate Cancer

Wang¹,

Yang²,

Zou³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

A number of studies have indicated that Nurr1, which belongs to a novel class of orphan nuclear receptors (the NR4A family), is important for carcinogenesis. Here we investigated expression of Nurr1 protein in benign and malignant human prostate tissues and association with clinicopathologic features using immunohistochemical techniques. Moreover, we also investigated the ability of Nurr1 to influence proliferation, migration, invasion and apoptosis of human prostate cancer cells using small interfering RNA silencing. Immunohistochemical analysis revealed that the expression of Nurr1 protein was higher in prostate cancer tissues than in benign prostate tissue (P < 0.001), levels being positively correlated with tumor T classification (P = 0.003), N classification (P = 0.017), M classification (P = 0.011) and the Gleason score (P = 0.020) of prostate cancer patients. In vitro, silencing of endogenous Nurr1 attenuated cell proliferation, migration and invasion, and induced apoptosis of prostate cancer cells. These results suggest that Nurr1 may be used as an indicator for prostate cancer progression and be useful for novel potential therapeutic strategies.

show abstract

Section: 2023 Orphan Nuclear Receptor Nurr1 Is a Novel Potential Marmentioning

confidence: 67%

“…Jian Wang 1 , Jing Yang 2 , Ying Zou 1 , Guo-Liang Huang 1 , Zhi-Wei He 1 * Sirin et al, 2010), apoptosis (Ke et al, 2004), migration (Maijenburg et al, 2012) and differentiation in a cell type-specific manner. Recently, the oncogenic activities of Nurr1 are emerging.…”

Section: Orphan Nuclear Receptor Nurr1 As a Potential Novel Marker Fomentioning

confidence: 99%

Orphan Nuclear Receptor Nurr1 as a Potential Novel Marker for Progression in Human Prostate Cancer

Wang¹,

Yang²,

Zou³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…NR4A2 is an orphan nuclear receptor and a member of the nerve growth factor I-B subfamily of transcription factors with no known endogenous ligand or stimulator. It is a key regulatory molecule in a number of biological processes, including regulation of proliferation, apoptosis, migration and differentiation in a cell type-specific manner (Ke et al, 2004;Bonta et al, 2010;Lee et al, 2010;Sirin et al, 2010;Maijenburg et al, 2012). Recently, the oncogenic activities of NR4A2 are emerging.…”

Section: Introductionmentioning

confidence: 99%

High Cytoplasmic Expression of the Orphan Nuclear Receptor NR4A2 Predicts Poor Survival in Nasopharyngeal Carcinoma

Wang

Yang²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…All of these hypoxic effects reinforce the migration capacity and the homing of transplanted cells to the lesion sites [73]. Maijenburg et al [76] investigated the process of MSC migration and found that nuclear receptors Nur77 and Nurr1 showed the highest expression in migratory MSCs. The expression of these receptors rapidly increased under stimulation with SDF-1α and platelet-derived growth factor (PDGF).…”

Section: Enhanced Migration and Homingmentioning

confidence: 99%

The role of the microenvironment on the fate of adult stem cells

Dong

Hao

Han

et al. 2015

Sci. China Life Sci.

View full text Add to dashboard Cite

Adult stem cells (SCs) exist in all tissues that promote tissue growth, regeneration, and healing throughout life. The SC niche in which they reside provides signals that direct them to proliferate, differentiate, or remain dormant; these factors include neighboring cells, the extracellular matrix, soluble molecules, and physical stimuli. In disease and aging states, stable or transitory changes in the microenvironment can directly cause SC activation or inhibition in tissue healing as well as functional regulation. Here, we discuss the microenvironmental regulation of the behavior of SC and focus on plasticity approaches by which various environmental factors can enhance the function of SCs and more effectively direct the fate of SCs.

show abstract

Nuclear ReceptorsNur77andNurr1Modulate Mesenchymal Stromal Cell Migration

Cited by 55 publications

References 55 publications

Orphan Nuclear Receptor Nurr1 as a Potential Novel Marker for Progression in Human Prostate Cancer

Orphan Nuclear Receptor Nurr1 as a Potential Novel Marker for Progression in Human Prostate Cancer

High Cytoplasmic Expression of the Orphan Nuclear Receptor NR4A2 Predicts Poor Survival in Nasopharyngeal Carcinoma

The role of the microenvironment on the fate of adult stem cells

Contact Info

Product

Resources

About