Nuclear receptors linking physiology and germline stem cells in Drosophila

Finger, Danielle S.; Whitehead, Kaitlin M.; Phipps, Daniel N.; Ables, Elizabeth T.

doi:10.1016/bs.vh.2020.12.008

Cited by 14 publications

(6 citation statements)

References 217 publications

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“…In particular, ecdysteroids are biosynthesized in the ovary where Halloween genes encoding ecdysteroidogenic enzymes are expressed ( Niwa and Niwa, 2014 ; Uryu et al, 2015 ; Ameku and Niwa, 2016 ). Also, ecdysteroid signaling in the ovary regulates a wide range of oogenesis processes, including the maintenance of female GSC numbers ( Ables and Drummond-Barbosa, 2010 ; König et al, 2011 ; Morris and Spradling, 2012 ; Ables et al, 2015 ; Ahmed et al, 2020 ; Finger et al, 2021 ). Additionally, 20E acts on both GSCs and the GSC niche cells to regulate the maintenance of female GSC numbers ( Ables and Drummond-Barbosa, 2010 ; König et al, 2011 ).…”

Section: Humoral Factors That Transmit Mating Stimuli To Female Germline Stem Cellsmentioning

confidence: 99%

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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In many insect species, mating stimuli can lead to changes in various behavioral and physiological responses, including feeding, mating refusal, egg-laying behavior, energy demand, and organ remodeling, which are collectively known as the post-mating response. Recently, an increase in germline stem cells (GSCs) has been identified as a new post-mating response in both males and females of the fruit fly, Drosophila melanogaster. We have extensively studied mating-induced increase in female GSCs of D. melanogaster at the molecular, cellular, and systemic levels. After mating, the male seminal fluid peptide [e.g. sex peptide (SP)] is transferred to the female uterus. This is followed by binding to the sex peptide receptor (SPR), which evokes post-mating responses, including increase in number of female GSCs. Downstream of SP-SPR signaling, the following three hormones and neurotransmitters have been found to act on female GSC niche cells to regulate mating-induced increase in female GSCs: (1) neuropeptide F, a peptide hormone produced in enteroendocrine cells; (2) octopamine, a monoaminergic neurotransmitter synthesized in ovary-projecting neurons; and (3) ecdysone, a steroid hormone produced in ovarian follicular cells. These humoral factors are secreted from each organ and are received by ovarian somatic cells and regulate the strength of niche signaling in female GSCs. This review provides an overview of the latest findings on the inter-organ relationship to regulate mating-induced female GSC increase in D. melanogaster as a model. We also discuss the remaining issues that should be addressed in the future.

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Section: Humoral Factors That Transmit Mating Stimuli To Female Germline Stem Cellsmentioning

confidence: 99%

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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“…From the comparative transcriptome analysis of M. rosenbergii , CYP315a1 was suggested involved in testicular development ( 42 ). Nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules ( 47 , 48 ). Steroid hormones are well known to be responsible for controlling reproduction and development in higher organisms like arthropods ( 46 , 47 ).…”

Section: Discussionmentioning

confidence: 99%

Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn

Chen

Wang

et al. 2022

Front. Endocrinol.

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The freshwater prawn Macrobrachium rosenbergii is one kind of important economic aquaculture species and displays remarkable sexual dimorphism. The molecular mechanism of sexual differentiation in M. rosenbergii has been primarily unraveled through the research efforts of the androgenic gland and its related genes. However, the understanding of conserved genes involved in the molecular mechanism underpinning sex determination and sexual differentiation of M. rosenbergii is still fragmentary. MroDmrt11E is a member of the doublesex and mab-3-related transcription factor (Dmrt) gene family and is prominently expressed in the testis. In the present study, in vivo knockdown of MroDmrt11E at the postlarva stage in male prawn induced a complete and functional sex reversal and achieved the production of an all-male monosex population. Furthermore, a great deal of new information of upregulated and downregulated transcriptions involved in sexual differentiation of MroDmrt11E knockdown was enriched by comparative transcriptomic analysis. The effects of RNAi-mediated gene knockdown of MroDmrt11E on the differentially expressed and sex-related candidate genes, such as transformer, fruitless, feminization, insulin-like androgenic gland gene, Dmrt gene family, were primarily focused on, and their possible molecular regulatory relationships in sexual differentiation were analyzed. Meanwhile, the response of primary Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathways was investigated to expound the potential roles of MroDmrt11E in male sexual differentiation, which provided a deeper understanding of the molecular regulatory network underlying sexual differentiation of M. rosenbergii. The finding provided a novel sexual manipulation technique through silencing of Dmrt gene family for achieving a complete and functional sex reversal and offered a new insight regarding the mechanism of the Dmrt gene family in the sexual differentiation of crustaceans.

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“…An alternative explanation, for which we have no direct evidence, is that P -element insertions into lncRNA:CR43651 impacts a trait that would be strongly selected in a lab selection experiment such as development time or fecundity. Interestingly, mir-14 is also a negative regulator of Ecdysone Receptor in D. melanogaste r (Varghese and Cohen 2007), which regulates several key physiological processes including pupation and oogenesis (reviewed in Thummel 1995; Schwedes and Carney 2012; Finger et al 2021). If P -element insertions exert their beneficial regulatory effects in non-ovarian tissue, such as in whole larvae, this would explain the absence of a systematic effect on mir14 expression in the ovary (Figure 5A, 5B).…”

Section: Discussionmentioning

confidence: 99%

TE invasion fuels molecular adaptation in laboratory populations of Drosophila melanogaster

Zhang

Wang

Hadjipanteli

et al. 2022

Preprint

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Transposable elements are mobile genetic parasites that frequently invade new host genomes through horizontal transfer. Invading TEs often exhibit a burst of transposition, followed by reduced transposition rates as repression evolves in the host. We recreated the horizontal transfer of P-element DNA transposons into a D. melanogaster host, and followed the expansion of TE copies and evolution of host repression in replicate laboratory populations reared at different temperatures. We observed that while populations maintained at high temperatures rapidly go extinct after TE invasion, those maintained at lower temperatures persist, allowing for TE spread and the evolution of host repression. We also surprisingly discovered that invaded populations experienced recurrent insertion of P-elements into a specific long non-coding RNA, lncRNA:CR43651, and that these insertion alleles are segregating at unusually high frequency in experimental populations, indicative of positive selection. We propose that, in addition to driving the evolution of repression, transpositional bursts of invading TEs can drive molecular adaptation.

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Nuclear receptors linking physiology and germline stem cells in Drosophila

Cited by 14 publications

References 217 publications

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn

TE invasion fuels molecular adaptation in laboratory populations of Drosophila melanogaster

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