Nuclear reprogramming: what has been done and potential avenues for improvements

Loi, Pasqualino; Matsukawa, Kazutsugu; Takahashi, Seiya; Akagi, Satoshi; Ptak, Grazyna

doi:10.2478/s11535-008-0025-6

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"Canonical" Interspecifi C Somatic Cells Nuclear Transfer (I1

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“…Put simply, the oocyte is unable in most cases to erase completely the differentiation memory accumulated in the form of epigenetic changes on the genome during development. Many excellent reviews are available on the topics, to which the reader is recommended (Gurdon and Wilmut 2011 ;Maruotti et al 2010 ;Loi et al 2008 ); in this chapter we would like to address exclusively the technical and biological aspects concerned with the cloning of a mammoth through a "canonical" ISCNT.…”

Section: "Canonical" Interspecifi C Somatic Cells Nuclear Transfer (Imentioning

confidence: 99%

Cloning the Mammoth: A Complicated Task or Just a Dream?

Loi

Saragusty

Ptak

2014

Advances in Experimental Medicine and Biology

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Recently there has been growing interest in applying the most advanced embryological tools, particularly cloning, to bring extinct species back to life, with a particular focus on the woolly mammoth (Mammuthus primigenius). Mammoth's bodies found in the permafrost are relatively well preserved, with identifiable nuclei in their tissues. The purpose of this chapter is to review the literature published on the topic, and to present the strategies potentially suitable for a mammoth cloning project, with a frank assessment of their feasibility and the ethical issues involved.

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Section: "Canonical" Interspecifi C Somatic Cells Nuclear Transfer (Imentioning

confidence: 99%