Nuclear Transport of Steroid Hormone Receptors

Shank, Leonard C.; Paschal, Bryce M.

doi:10.1615/critreveukargeneexpr.v15.i1.40

Cited by 6 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ligand binding may instead regulate a critical chaperone‐dependent step that occurs after NLS recognition by the import machinery (104–106). Chaperones have also been shown to facilitate nuclear receptor interactions with the cytoskeleton, suggesting that there may be subcellular locales for cytoplasmic retention and/or transformation (96).…”

Section: Nuclear Transport Of Steroid Hormone Receptorsmentioning

confidence: 99%

“…Nuclear import of GR can be triggered by shear stress activation of MAP and PI‐3 kinases (119). MAP kinases have also been implicated in the regulation of ER, PR and GR export (96). In the case of PR, epidermal growth factor signalling through the MAP kinase pathway results in PR phosphorylation, nuclear export and degradation in the cytoplasm (120).…”

Section: Nuclear Transport Of Steroid Hormone Receptorsmentioning

confidence: 99%

“…Although it has been known for some time that nuclear receptors such as the glucocorticoid receptor (GR) undergo ligand-dependent import, new information on the molecular basis of nuclear receptor import is emerging. Nuclear receptors also undergo nuclear export, and the combined importexport cycle, or nucleocytoplasmic shuttling, has been viewed as a potential mechanism for terminating transcription, and for integrating transcription with signalling events in the cytoplasm (95,96). Nuclear export could also regulate the participation of nuclear receptors in non-genomic functions in the cytoplasm.…”

Section: Nuclear Transport Of Steroid Hormone Receptorsmentioning

confidence: 99%

See 2 more Smart Citations

Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export

Pemberton

Paschal

2005

Traffic

Self Cite

634

599

View full text Add to dashboard Cite

Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is mediated by a superfamily of transport receptors known collectively as karyopherins. Karyopherins bind to their cargoes by recognition of specific nuclear localization signals or nuclear export signals. Transport through the nuclear pore complex is facilitated by transient interactions between the karyopherins and the nuclear pore complex. The interactions of karyopherins with their cargoes are regulated by the Ras-related GTPase Ran. Ran is assisted in this process by proteins that regulate its GTPase cycle and subcellular localization. In this review, we describe several of the major transport pathways that are conserved in higher and lower eukaryotes, with particular emphasis on the role of Ran. We highlight the latest advances in the structure and function of transport receptors and discuss recent examples of steroid hormone receptor import and regulation by signal transduction pathways. Understanding the molecular basis of nuclear transport may provide insight into human diseases by revealing how nucleocytoplasmic trafficking regulates protein activity.

show abstract

Section: Nuclear Transport Of Steroid Hormone Receptorsmentioning

confidence: 99%

Section: Nuclear Transport Of Steroid Hormone Receptorsmentioning

confidence: 99%

Section: Nuclear Transport Of Steroid Hormone Receptorsmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export

Pemberton

Paschal

2005

Traffic

Self Cite

634

599

View full text Add to dashboard Cite

show abstract

“…Recent data suggest that steroid‐binding may regulate a chaperone‐dependent step that occurs after recognition of the NLS in these receptors (Davies et al , 2002; Freedman and Yamamoto, 2004). Nucleocytoplasmic shuttling of steroid receptors also provides a nexus for crosstalk with kinase stress pathways (Shank and Paschal, 2005). For example, epidermal growth factor signalling through a MAP kinase pathway leads to phosphorylation of the progesterone receptor, MAP kinase‐dependent nuclear export, and subsequent degradation in the cytoplasm (Qiu et al , 2003).…”

Section: Folding Stabilization and Degradation Of Plant And Animal mentioning

confidence: 99%

Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors

Shen

Schulze‐Lefert

2007

EMBO J

View full text Add to dashboard Cite

Plants and animals have evolved structurally related innate immune sensors inside cells to detect the presence of microbial molecules. An evolutionary ancient folding machinery becomes engaged for the synthesis of autorepressed receptor forms in both kingdoms. The receptors act as regulatory signal transduction switches and are activated upon direct or indirect perception of non-self structures. Recent findings indicate that nucleo-cytoplasmic partitioning and nuclear activity is critical for the function of several plant immune sensors, thereby linking receptor function to transcriptional reprogramming of host cells for pathogen defense. This implies short signalling pathways and reveals parallels with regulatory control mechanisms of animal steroid receptors.

show abstract

“…Among the transcription factors, the NR (nuclear receptor) superfamily is a large group of ligand‐modulated transcription factors with 49 members presently identified. These transcription factors are implicated in numerous physiological processes, and have been prospective therapeutic targets for treatment of many critical diseases including hormone‐related cancers (Evans, 1998; Escriva et al, 2004; Shank and Paschal, 2005; Kumar et al, 2006; McEwan, 2009). In view of the fact that ligand‐induced movements and localization of transcription factors are one of the major phenomena for regulating the transcriptional activity, FP (fluorescent protein)‐tagged NR chimaera have been consistently used for studying their dynamic behaviour in living cells (Shank and Paschal, 2005; Kumar et al, 2006; Griekspoor et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Retention and transmission of active transcription memory from progenitor to progeny cells via ligand‐modulated transcription factors: elucidation of a concept by BIOPIT model

Kumar¹,

Mallampati²,

Chaturvedi³

et al. 2012

Cell Biology International

View full text Add to dashboard Cite

Observations made in live cells have clearly demonstrated that agonist-activated steroid/nuclear receptors reorganize in the nucleoplasm into hundreds of discrete speckled structures commonly referred to as nuclear foci. Subsequent studies have shown that nuclear foci are formed only with agonist- and not with pure antagonist-bound receptors. Also, the other accessory components of transcriptional machinery co-localize in nuclear foci with the activated receptors, suggesting these to be active gene transcription sites. Recently, it has been observed that during mitosis nuclear foci present in interphase of progenitor cells co-migrate with condensing chromatin and are inherited into the progeny cells. Ensuing events imply that as memory, the cells inherit only a biomolecular blueprint of transcription status over to next generations to express and sustain their characteristic proteome. Thus, cells achieve self-renewal via mitosis but not without ensuring that the characteristic proteome and traits are distinctively preserved during this transcription phase. This mechanism, although somewhat analogous to epigenetic marking, differs in Nature since transcription factors themselves execute this transmission. To uphold the mechanistic distinctions the phenomenon has been termed BIOPIT (biomolecular imprints offered to progeny for inheritance of traits). The BIOPIT model proposed herein attempts to explain how the disruption of BIOPIT markings by therapeutic anti-hormones or endocrine disruptors over prolonged periods may lead to eradication of cellular transcription memory with deleterious cellular consequences. It is anticipated that our model has the potential to explain the concerted actions and consequences of ligand-receptor interactions with the chromatin in the perspective of normal and aberrant physiological situations.

show abstract

Nuclear Transport of Steroid Hormone Receptors

Cited by 6 publications

References 0 publications

Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export

Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export

Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors

Retention and transmission of active transcription memory from progenitor to progeny cells via ligand‐modulated transcription factors: elucidation of a concept by BIOPIT model

Contact Info

Product

Resources

About