Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors

Shen, Qian‐Hua; Schulze‐Lefert, Paul

doi:10.1038/sj.emboj.7601854

Cited by 68 publications

(46 citation statements)

References 91 publications

(128 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The perception of MAMPs or MIMPs by R protein receptors causes a quantitatively and kinetically different response leading to the hypersensitive response (HR), which is a form of programmed cell death. However, both types of defense response show similar patterns, so it is possible that they involve each other's signaling pathways [23].…”

Section: Molecular Models Of Pathogen Recognitionmentioning

confidence: 99%

“…The perception of MAMPs by PRR triggers an immune response within minutes. The types of immune response include an increase in the intracellular Ca 2+ concentration, which is indispensable for initiating signaling pathways, an oxidative burst, or an induction of mitogen-activated protein kinases (MAPKs) [20][21][22][23]. The perception of MAMPs or MIMPs by R protein receptors causes a quantitatively and kinetically different response leading to the hypersensitive response (HR), which is a form of programmed cell death.…”

Section: Molecular Models Of Pathogen Recognitionmentioning

confidence: 99%

See 1 more Smart Citation

R proteins as fundamentals of plant innate immunity

Głowacki

Macioszek

Kononowicz

2011

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

Abstract:Plants are attacked by a wide spectrum of pathogens, being the targets of viruses, bacteria, fungi, protozoa, nematodes and insects. Over the course of their evolution, plants have developed numerous defense mechanisms including the chemical and physical barriers that are constitutive elements of plant cell responses locally and/or systemically. However, the modern approach in plant sciences focuses on the evolution and role of plant protein receptors corresponding to specific pathogen effectors. The recognition of an invader's molecules could be in most cases a prerequisite sine qua non for plant survival. Although the predicted three-dimensional structure of plant resistance proteins (R) is based on research on their animal homologs, advanced technologies in molecular biology and bioinformatics tools enable the investigation or prediction of interaction mechanisms for specific receptors with pathogen effectors. Most of the identified R proteins belong to the NBS-LRR family. The presence of other domains (including the TIR domain) apart from NBS and LRR is fundamental for the classification of R proteins into subclasses. Recently discovered additional domains (e.g. WRKY) of R proteins allowed the examination of their localization in plant cells and the role they play in signal transduction during the plant resistance response to biotic stress factors. This review focuses on the current state of knowledge about the NBS-LRR family of plant R proteins: their structure, function and evolution, and the role they play in plant innate immunity.

show abstract

Section: Molecular Models Of Pathogen Recognitionmentioning

confidence: 99%

Section: Molecular Models Of Pathogen Recognitionmentioning

confidence: 99%

R proteins as fundamentals of plant innate immunity

Głowacki

Macioszek

Kononowicz

2011

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

show abstract

“…Whether specific R proteins are required for the small-molecule DFPM-induced response remains unknown. Depending on their N-terminal domain, R proteins are generally divided into two groups, coiled-coil (CC)-nucleotide binding (NB)-leucine-rich repeat (LRR) and Toll-Interleukin1 Receptor (TIR)-NB-LRR (Meyers et al, 2003;Belkhadir et al, 2004;Chisholm et al, 2006;DeYoung and Innes, 2006;Shen and Schulze-Lefert, 2007;Caplan et al, 2008). The genome of Arabidopsis thaliana contains ;150 NB-LRR genes, and up to 600 genes are found in rice (Oryza sativa; Kadota et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Natural Variation in Small Molecule–Induced TIR-NB-LRR Signaling Induces Root Growth Arrest via EDS1- and PAD4-Complexed R Protein VICTR inArabidopsis

et al. 2012

View full text Add to dashboard Cite

In a chemical genetics screen we identified the small-molecule [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione (DFPM) that triggers rapid inhibition of early abscisic acid signal transduction via PHYTOALEXIN DEFICIENT4 (PAD4)-and ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)-dependent immune signaling mechanisms. However, mechanisms upstream of EDS1 and PAD4 in DFPM-mediated signaling remain unknown. Here, we report that DFPM generates an Arabidopsis thaliana accession-specific root growth arrest in Columbia-0 (Col-0) plants. The genetic locus responsible for this natural variant, VICTR (VARIATION IN COMPOUND TRIGGERED ROOT growth response), encodes a TIR-NB-LRR (for Toll-Interleukin1 Receptornucleotide binding-Leucine-rich repeat) protein. Analyses of T-DNA insertion victr alleles showed that VICTR is necessary for DFPM-induced root growth arrest and inhibition of abscisic acid-induced stomatal closing. Transgenic expression of the Col-0 VICTR allele in DFPM-insensitive Arabidopsis accessions recapitulated the DFPM-induced root growth arrest. EDS1 and PAD4, both central regulators of basal resistance and effector-triggered immunity, as well as HSP90 chaperones and their cochaperones RAR1 and SGT1B, are required for the DFPM-induced root growth arrest. Salicylic acid and jasmonic acid signaling pathway components are dispensable. We further demonstrate that VICTR associates with EDS1 and PAD4 in a nuclear protein complex. These findings show a previously unexplored association between a TIR-NB-LRR protein and PAD4 and identify functions of plant immune signaling components in the regulation of root meristematic zone-targeted growth arrest.

show abstract

“…In Arabidopsis, 51 TNL and 39 CNL proteins possess predicted monopartite or bipartite nuclear localization signals (NLSs) (Shen and Schulze-Lefert, 2007). Multiple studies have drawn attention to the nucleo-cytoplasmic trafficking of plant NLR proteins and their functions in the nucleus (Figure 3) (reviewed in Liu and Coaker, 2008).…”

Section: Diverse Nlr Subcellular Localizationsmentioning

confidence: 99%