Nucleation behaviour of racemic and enantiopure histidine

Abstract

Small non-centrosymmetric domains are observed in the racemic crystal, due to the low nucleation activation energy of the conglomerate.

Reinvestigating the Preferential Enrichment of DL-Arginine Fumarate: New Thoughts on the Mechanism of This Far from Equilibrium Crystallization Phenomenon

“…Although In-SituX ® experiments revealed the occurrence of slight peak shifts occurring during the process (Figures S2-S4), the ArgFum crystals obtained after 14 4h of PE were analyzed by SHG. This technique is sensitive to non-centrosymmetry in crystals and successfully evidenced the presence of enantio-enriched zones in 'racemic' crystals of histidine which exhibits a weak PE effect [30]. Figure 8a shows the presence of few and localized zones of noncentrosymmetry (in green) inside the ArgFum crystals (ca.…”

Nucleation Kinetics of Ascorbic Acid in Various Aqueous Solvents

“…These applications include laser-induced crystallization, 19 template-assisted crystallization, 20,21 ultrasound-assisted crystallization, 22 examining the influence of impurities on nucleation processes 23,24 and determining vital parameters such as the critical size of nuclei, activation energy, and growth rates. 25,26 Nucleation occurs when supersaturation is formed in the particular solvent; hence solvent properties play a significant role in analyzing the nucleation rate via solute−solvent intermolecular interaction. 27−31 Yang et al have studied the effect of solvent properties on the nucleation kinetics of hexamethylene-bis-triacetone diamine from various ester solvents in terms of interfacial energy, critical radius, number of nuclei, and Gibbs free energy.…”

“…Subsequently, this methodology has been extensively adopted by various researchers for a diverse range of studies in nucleation kinetics. These applications include laser-induced crystallization, template-assisted crystallization, , ultrasound-assisted crystallization, examining the influence of impurities on nucleation processes , and determining vital parameters such as the critical size of nuclei, activation energy, and growth rates. , …”

Prediction of metastable zone widths of ammonium sulphate: modification of the nucleation potential model in an electrolyte system

“…In addition, the pre-exponential factor and the solid-liquid interfacial energy can be further calculated based on CNT, both of which provide relevant information about the collision of molecules and the surface of nuclei, respectively, helping to facilitate a deeper understanding of the nucleation process. [21][22][23][24][25] In previous studies, the nucleation potential model was extrapolated from the classical nucleation theory, 26,27 to bridge the nucleation parameters with the polythermal method (MSZWs) and the isothermal method (induction time), and estimate the MSZWs from the induction time or the induction time from MSZWs in many systems, such as paraben, isonicotinamide, paracetamol, and salicylic acid. [26][27][28] The nucleation process of ammonium sulphate crystallization has been reported.…”