Nucleation of calcium phosphate by surface‐bound extracellular matrix

Pham, M.T.; Maitz, Manfred F.; Reuther, H.; Muecklich, A.; Prokert, F.; Steiner, Gerald

doi:10.1002/jbm.a.30113

Cited by 5 publications

(12 citation statements)

References 32 publications

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“…Pham et al18 also reported the formation of apatite on silicon surfaces that had been modified with ECM. The biological process of laying ECM through osteoblast‐like cells certainly enhanced the formation of apatite on silicon.…”

Section: Discussionmentioning

confidence: 98%

“…It is a relatively simple and low cost process to induce the formation of apatite on silicon substrates. Other techniques, such as ion implantation,15, 16 modification with ECM,18 and precipitation deposition of apatite,44 are also studied for improving the bioactivity of silicon substrates. Liu et al16 reported the formation of apatite on amorphous hydrogenated silicon surface, modified through ion implantation.…”

Section: Discussionmentioning

confidence: 99%

“…Dahmen et al has also shown that chemical modification and functionalization of hydrogenated amorphous silicon and silicon sub‐oxides do make these materials promising for biological applications 17. Extracellular matrix (ECM) laid by osteoblast‐like cells on silicon surfaces have also shown to promote nucleation of calcium phosphate 18. The formation of an apatite layer on silicon will therefore increase the biocompatibility and bioactivity of silicon, and this will facilitate the implantation of silicon‐based microelectronic devices (e.g., biochips, biosensors, MEMS) in vivo or for other biological applications.…”

Section: Introductionmentioning

confidence: 99%

“…Though silicon‐based biomedical devices and implants have undergone tremendous development, the bioactivity and biocompatibility of silicon is still relatively not well understood. Till date, some attempts have been made to improve the bioactivity and biocompatibility of silicon wafers by inducing an apatite layer through deposition13, 14 or a biomimetic process 15–20. The biomimetic synthesis to produce an apatite layer is a low‐temperature technique that imitates the natural biomineralization during bone formation in vivo .…”

Section: Introductionmentioning

confidence: 99%

“…The biomimetic synthesis to produce an apatite layer is a low‐temperature technique that imitates the natural biomineralization during bone formation in vivo . This biomimetic process of producing apatite layers on silicon substrates has shown to be enhanced by surface modification of the substrate 15–19. For instance, Liu et al has reported that the bioactivity of silicon can be enhanced by hydrogen plasma immersion ion implantation (PIII) 15, 16.…”

Section: Introductionmentioning

confidence: 99%

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Biomimetic processing of bioactive interface on silicon substrates

et al. 2007

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To facilitate the implantation of silicon-based devices in vivo, the presence of a biocompatible and bioactive coating is noted to be an essential factor. The objective of this present work is therefore to explore a relatively simple and low cost process to induce the formation of bioactive apatite on silicon. The formation of apatite on silicon was carried out by a biomimetic approach on two orientations of silicon wafer, namely (100) and (111). The samples are functionalized by chemical etching, followed by incubation in a simulated body fluid. Scanning electron microscopy, energy dispersive X-ray analysis, X-ray diffraction analysis, and X-ray photoelectron spectroscopy were carried out. It was found that the growth of apatite is dependent on the orientation of the silicon wafer. Cell culturing experiment further verified the biological performance of the apatite-coated silicon samples.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomimetic processing of bioactive interface on silicon substrates

et al. 2007

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Bioactivity and cytocompatibility of silicon wafers treated by water

Niu

Liu

Ding

2007

J Biomedical Materials Res

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A range of bioactive ceramics can induce bone-like apatite to deposit on their surface in simulated body fluid (SBF). In this work, the silicon wafer was treated using deionized water to improve its bioactivity. The morphology and chemical composition of the treated silicon wafer was examined using Fourier transform infrared spectroscopy, atomic force microscopy and X-ray photoelectron spectroscopy. Field emission scanning electron microscopy was used to observe the surface morphologies of silicon wafers soaked in SBF. The results indicated that a hydrated sub-oxide film having Si--OH groups formed on the surface of the silicon wafer after the water treatment. The amount of Si--OH groups increased with raising the treatment temperature or prolonging the immersion time. Apatite was deposited on the surface of water-treated silicon wafers immersed in SBF. The apatite deposition was correlated with the amount of Si--OH groups. Human mesenchymal stem cells cultured on the surface of the water-treated silicon wafers showed good adhesion and spread, indicating that the cytocompatibility of silicon wafer was enhanced by this water treatment.

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