Nucleo-copolymers: oligonucleotide-based amphiphilic diblock copolymers

Teixeira, Francisco José Soares; Rigler, Per; Vebert-Nardin, Corinne

doi:10.1039/b617109e

Cited by 55 publications

(60 citation statements)

References 8 publications

(8 reference statements)

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“…[112] Biohybrid 'giant-amphiphiles' consisting of a synthetic polymer chain linked to a functional protein can form vesicles that retain the enzymatic activity of the protein. [113,114] Vesicles with biologically relevant coronal hydrophilic moieties have also been developed from both oligonucleotide dCMP sequences [115] and polysaccharides. [116][117][118] Biocompatible Copolymer Vesicles and the Delivery of Actives…”

Section: Reactive and Environmentally Responsive Membranes For Delivementioning

confidence: 99%

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Blanazs

Armes

Ryan

2009

Macromol. Rapid Commun.

1,410

1,370

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The ability of amphiphilic block copolymers to self‐assemble in selective solvents has been widely studied in academia and utilized for various commercial products. The self‐assembled polymer vesicle is at the forefront of this nanotechnological revolution with seemingly endless possible uses, ranging from biomedical to nanometer‐scale enzymatic reactors. This review is focused on the inherent advantages in using polymer vesicles over their small molecule lipid counterparts and the potential applications in biology for both drug delivery and synthetic cellular reactors.magnified image

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Section: Reactive and Environmentally Responsive Membranes For Delivementioning

confidence: 99%

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Blanazs

Armes

Ryan

2009

Macromol. Rapid Commun.

1,410

1,370

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“…4A). 41 Thereby, the isolation of the vesicular interior from the surrounding medium by a DBC double-layer was demonstrated using fluorescence probes. Although the material stability and duplex formation capability have not yet been studied, the novel behavior of this DNA hybrid suggests further investigations of such AON structures.…”

Section: Preparation Of Aons Without a Dna Synthesizermentioning

confidence: 99%

Nucleic acid amphiphiles: synthesis and self-assembled nanostructures

2011

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This review provides an overview of a relatively new class of bio-conjugates, DNA amphiphiles, which consist of oligonucleotides covalently bonded to synthetic hydrophobic units. The reader will find the basic principles for the structural design and preparation methods of the materials. Moreover, the self-assembly into superstructures of higher order will be highlighted. Finally, some potential applications will be described.

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“…Vesicles with an oligonucleotide corona have been produced by the self-assembly of block copolymers with a hydrophobic PBD block and a hydrophilic oligonucleotide block [98,99]. The diblock copolymers were synthesized by linking an amine-terminated PBD to a carboxy-modified, 12-mer oligonucleotide sequence on the solid support on which the oligonucleotide had been synthesized.…”

Section: Formation Of Polymersomes From Polymers Comprising Biofunctimentioning

confidence: 99%

Functionalization of Block Copolymer Vesicle Surfaces

et al. 2011

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Abstract:In dilute aqueous solutions certain amphiphilic block copolymers self-assemble into vesicles that enclose a small pool of water with a membrane. Such polymersomes have promising applications ranging from targeted drug-delivery devices, to biosensors, and nanoreactors. Interactions between block copolymer membranes and their surroundings are important factors that determine their potential biomedical applications. Such interactions are influenced predominantly by the membrane surface. We review methods to functionalize block copolymer vesicle surfaces by chemical means with ligands such as antibodies, adhesion moieties, enzymes, carbohydrates and fluorophores. Furthermore, surface-functionalization can be achieved by self-assembly of polymers that carry ligands at their chain ends or in their hydrophilic blocks. While this review focuses on the strategies to functionalize vesicle surfaces, the applications realized by, and envisioned for, such functional polymersomes are also highlighted.

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Nucleo-copolymers: oligonucleotide-based amphiphilic diblock copolymers

Abstract: For the first time, poly(butadiene) has been covalently linked to an oligonucleotide sequence and the resulting nucleo-copolymer exhibits amphiphilic properties in dilute aqueous solution, self-assembling into nanometer-sized vesicular structures.

Cited by 55 publications

References 8 publications

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Nucleic acid amphiphiles: synthesis and self-assembled nanostructures

Functionalization of Block Copolymer Vesicle Surfaces

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