Nucleocapsid Protein residues 35, 36, and 113 are critical sites in up- regulating the Interleukin-8 Production via C/EBPα pathway by Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus
Abstract:Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious and pathogenic agent that causes considerable economic damage in the swine industry. It regulates the inflammatory response, triggers inflammation-induced tissue damage, suppresses the innate immune response, and leads persistent infection. Interleukin-8 (IL-8), a pro-inflammatory chemokine, plays a crucial role in inflammatory response during numerous bacteria and virus infections. However, the underlying mechanisms of IL-8 reg… Show more
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