Nucleolar organiser regions in myeloma and benign paraproteinaemia

Bryan, R L; Jan-Mohamed, Riaz; Crocker, J; Leyland, M. J.

doi:10.1038/bjc.1990.144

Cited by 2 publications

(1 citation statement)

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“…18 19 The AgNOR count has also been found to correlate well with plasma cell proliferative activity, measured by bromodeoxyuridine or proliferating cell nuclear antigen expression. 20 21 However, another study did not show any diVerence in AgNOR count between multiple myeloma and monoclonal gammopathy of undetermined importance, 22 although it is known that the mitotic potential of the plasma cells is one of the most reliable diVerentiating features of the two conditions. 23 Our data do not allow us to draw conclusions on the association between AgNOR count and proliferative activity in multiple myeloma, but we did not find a clear prognostic value for AgNOR enumeration in our study population.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of argyrophilic nucleolar organiser regions (AgNORs) in multiple myeloma

Papadhimitriou

Daskalopoulou²,

Tsaftaridis³

et al. 2000

Journal of Clinical Pathology

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Conclusions-Unlike previous investigations, no clear prognostic value for the AgNOR count was found in multiple myeloma. Instead, the results indicate that the AgNOR count might be an index for M protein synthesis rate. This is consistent with other findings in tissues with low proliferative potential and high protein synthetic activity, and calls for a cautious interpretation of AgNORs in malignancies with similar features. (J Clin Pathol 2000;53:462-465)

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Section: Discussionmentioning

confidence: 98%