(2015) 1550-7998=2015=92 (7)=072015 (29) 072015-1 © 2015 American Physical Society University of California at Irvine, Irvine, California 92697, USA Charge asymmetry in the processes e þ e − → μ þ μ − γ and e þ e − → π þ π − γ is measured using 232 fb −1 of data collected with the BABAR detector at e þ e − center-of-mass energies near 10.58 GeV. An observable is introduced and shown to be very robust against detector asymmetries while keeping a large sensitivity to the physical charge asymmetry that results from the interference between initial-and final-state radiation (FSR). The asymmetry is determined as a function of the invariant mass of the final-state tracks from production threshold to a few GeV=c 2 . It is compared to the expectation from QED for e þ e − → μ þ μ − γ, and from theoretical models for e þ e − → π þ π − γ. A clear interference pattern is observed in e þ e − → π þ π − γ, particularly in the vicinity of the f 2 ð1270Þ resonance. The inferred rate of lowest-order FSR production is consistent with the QED expectation for e þ e − → μ þ μ − γ, and is negligibly small for e þ e − → π þ π − γ.