Nucleus accumbens core and shell inactivation differentially affects impulsive behaviours in rats

Feja, Malte; Hayn, Linda; Koch, Michael

doi:10.1016/j.pnpbp.2014.04.012

Cited by 63 publications

(39 citation statements)

References 131 publications

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“…Importantly, NAc responds to anticipated rewards [30] and plays a critical role in pathological gambling [31], aggression [32], and addiction [33]. NAc has also been implicated in impulsivity, as lesions to NAc core increase impulsive choice in rats [34–37], and inactivation of NAc shell increases impulsivity in the five choice serial reaction time (5CSRT) task [38]. Furthermore, decreased NAc activation is observed following reward omission in humans [39].…”

Section: Discussionmentioning

confidence: 99%

Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency

Yates

Darna

Gipson

et al. 2015

Behavioural Brain Research

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Negative urgency is a facet of impulsivity that reflects mood-based rash action and is associated with various maladaptive behaviors in humans. However, the underlying neural mechanisms of negative urgency are not fully understood. Several brain regions within the mesocorticolimbic pathway, as well as the neurotransmitters dopamine (DA) and serotonin (5-HT), have been implicated in impulsivity. Extracellular DA and 5-HT concentrations are regulated by DA transporters (DAT) and 5-HT transporters (SERT); thus, these transporters may be important molecular mechanisms underlying individual differences in negative urgency. The current study employed a reward omission task to model negative urgency in rats. During reward trials, a cue light signaled the non-contingent delivery of one sucrose pellet; immediately following the non-contingent reward, rats responded on a lever to earn sucrose pellets (operant phase). Omission trials were similar to reward trials, except that non-contingent sucrose was omitted following the cue light prior to the operant phase. As expected, contingent responding was higher following omission of expected reward than following delivery of expected reward, thus reflecting negative urgency. Upon completion of behavioral training, Vmax and Km were obtained from kinetic analysis of [3H]DA and [3H]5-HT uptake using synaptosomes prepared from nucleus accumbens (NAc), dorsal striatum (Str), medial prefrontal cortex (mPFC), and orbitofrontal cortex (OFC) isolated from individual rats. Vmax for DAT in NAc and for SERT in OFC were positively correlated with negative urgency scores. The current findings suggest that mood-based impulsivity (negative urgency) is associated with enhanced DAT function in NAc and SERT function in OFC.

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Section: Discussionmentioning

confidence: 99%

Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency

Yates

Darna

Gipson

et al. 2015

Behavioural Brain Research

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“…Decreased levels of the GABA receptor GAD65/67 in the accumbens core was related to both decreased gray matter in the accumbens core and higher impulsivity, and experimentally reducing GAD65/67 receptors in the accumbens core bilaterally in low impulsive animals increased impulsivity [56]. In line with these findings, inactivation of the accumbens core by the GABA A agonist musimol resulted in global impairments in 5CSRTT performance, and inactivation of the shell induced specific impulse-control deficits [57]. GABAergic projections have been less well investigated in the context of addiction although GABAergic mechanisms influence function of the mesolimbic pathway [58].…”

Section: Underlying Neurocircuitry Of Impulsivitiesmentioning

confidence: 98%

Recent Insights into the Neurobiology of Impulsivity

Mitchell

Potenza

2014

Curr Addict Rep

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Impulsivity is associated with various psychopathologies, and elevated impulsivity is typically disadvantageous. This manuscript reviews recent investigations into the neurobiology of impulsivity using human imaging techniques and animal models. Both human imaging and preclinical pharmacological manipulations have yielded important insights into the neurobiological underpinnings of impulsivity. A more thorough understanding of the complex neurobiology underlying aspects of impulsivity may provide insight into new treatment options that target elevated impulsivity and psychopathologies such as addictions.

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“…Along similar lines, other studies have used assays where discrete presentation of two discriminative cues signals different periods where rewards are or are not forthcoming. Suppression of activity within the NAc shell increased Pavlovian or instrumental responding during presentation of cues explicitly unpaired with rewards as well as during intervals when neither the cues nor rewards were available (Ambroggi et al 2011, Blaiss & Janak 2009, Feja et al 2014. The shell may also suppress goal-irrelevant behavior in situations requiring choice between rewards of different magnitudes.…”

Section: The Nucleus Accumbens Shell: Stay On Taskmentioning

confidence: 99%

The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action

Floresco

2015

Annu. Rev. Psychol.

710

582

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Nearly 40 years of research on the function of the nucleus accumbens (NAc) has provided a wealth of information on its contributions to behavior but has also yielded controversies and misconceptions regarding these functions. A primary tenet of this review is that, rather than serving as a "reward" center, the NAc plays a key role in action selection, integrating cognitive and affective information processed by frontal and temporal lobe regions to augment the efficiency and vigor of appetitively or aversively motivated behaviors. Its involvement in these functions is most prominent when the appropriate course of action is ambiguous, uncertain, laden with distractors, or in a state of flux. To this end, different subregions of the NAc play dissociable roles in refining action selection, promoting approach toward motivationally relevant stimuli, suppressing inappropriate actions so that goals may be obtained more efficiently, and encoding action outcomes that guide the direction of subsequent ones.

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Nucleus accumbens core and shell inactivation differentially affects impulsive behaviours in rats

Cited by 63 publications

References 131 publications

Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency

Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency

Recent Insights into the Neurobiology of Impulsivity

The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action

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