Null-Type Anaplastic Lymphoma Kinase–Negative Anaplastic Large Cell Lymphoma Arising in a Silicone Breast Implant Capsule

U.S. Epidemiology of Breast Implant–Associated Anaplastic Large Cell Lymphoma

“…8 Similarly, a case report by Lazzeri et al 9 Based on these data, we believe that our study makes a reasonable assumption that all cases of BI-ALCL have occurred with textured breast implants, as no cases of BI-ALCL have ever been confirmed in patients who received only smooth implants. However, in the documented cancer history, they state that it was unknown whether the original breast implant was textured, and it was followed by multiple subsequent implant exchanges.…”

“…4 Most cases have been diagnosed during revision surgery for a delayed or persistent seroma, associated with breast pain or swelling, occurring on average 9 years after implantation. 8, 9 However, these reports are questionable as the clinical history given in both case reports reveals that the implant surface was unknown or the implant had been replaced multiple times with other types of implants that were incompletely documented. 4,6,7 There have been only two reports in the literature indicating BI-ALCL may have occurred in association with a smooth silicone gel implant.…”