Number of External Anogenital Warts is Associated with the Occurrence of Abnormal Cervical Cytology

Chayachinda, Chenchit; Boriboonhirunsarn, Dittakarn; Thamkhantho, Manopchai; Nuengton, Chanon; Chalermchockcharoenkit, Amphan

doi:10.7314/apjcp.2014.15.3.1177

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…A previous study on genital warts in Thailand found that around 40% of women presenting with external anogenital warts who were not immunocompromised had recurrent warts within 6 months after completing the treatment [22]. Approximately 90% of genital warts are caused by low-risk genotypes HPV6 and HPV11 [23].…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus in Thai Women and Men with Anogenital Warts

et al. 2018

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Objective: Anogenital warts are caused by human papillomavirus (HPV). Globally, HPV genotypes 6 and 11 are most often associated with anogenital warts. However, the diversity of HPV genotypes found in patients with genital warts in Thailand is unknown. The aim of this study was to investigate HPV-associated anogenital warts in the Thai population and to assess whether genotypes found are represented in the bivalent and quadrivalent HPV vaccine. Methods: This study included 206 anogenital swab samples from patients who were diagnosed with anogenital warts. Detection of HPV DNA was performed using polymerase chain reaction to amplify the L1 gene and sequencing. Results: HPV was identified in 88.3% (182/206) of the samples. The majority of HPV genotypes were low-risk genotypes HPV6 (36.9%) and HPV11 (36.4%), which represented the most common infection found in genital warts in this study. Conclusion: Immunization with the quadrivalent vaccine (HPV6, HPV11, HPV16, and HPV18) could potentially prevent genital warts caused by HPV infection.

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus in Thai Women and Men with Anogenital Warts

et al. 2018

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“…Yaygın görüşe göre düşük riskli grubunda bulunan özellikle Human Papillomavirüs(HPV) tip-6 ve HPV tip-11 enfeksiyonu sonucu oluşmaktadır. Son yıllarda HPV tiplemesinin yaygınlaşması ile birlikte, genital kondillom hastalarının belli oranlarda yüksek riskli HPV tiplerinden de oluşabileceği görülmüştür (5)(6)(7)(8).…”

Section: Introductionunclassified

Genital siğili olan kadınlarda servikal HPV ve servikal smear sonuçlarının karşılaştırılması

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et al. 2020

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Genital siğili olan kadınlarda lezyona neden olan HPV tipini belirlemek ve bu kadınlarda servikal HPV ile sitoloji örnekleriyle karşılaştırmak. Gereç ve Yöntem Hastanemize nisan 2014-nisan 2015 tarihleri arasında genital siğil nedeniyle başvuran kadınlardan lezyon üzerinden ve servikal sürüntüden HPV tiplendirilmesi yapılıp servikal sitolojileri incelendi. Çalışma prospektif bir çalışma olup hastanemiz etik kurulundan onay alınmış, çalışmaya katılmayı kabul eden kadınlara gerekli bilgilendirme yapılarak aydınlatılmış rıza belgesi alınmıştır. Çalışmamıza uygun olup rıza veren 44 kadın incelendi.

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“…HPV genotyping distribution studies of genital warts in the Thai population and within Southeast Asian region are limited. A previous study on the genital warts in Thailand found that around 40% of women presenting with external anogenital warts who were not immunocompromised had recurrent warts within 6 months after completing the treatment (145). Benign lesions found in 90% of genital warts are caused by low-risk genotypes HPV6 and HPV11 (1).…”

Section: Discussionmentioning

confidence: 99%

Assessment?of?human?papillomavirus?detection?using?different?methods?and?clinical?samples

Nilyanimit

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Human papillomavirus (HPV) is the etiological agent implicated cancers include those of the cervix, vulva, vagina, penis, anus, rectum and oropharynx. Currently, the Papanicolaou (Pap) smear is the recommended for cervical cancer screening but only a small percentage of women follow this screening. Overall, this thesis aimed to develop the technique and type of specimen to detect HPV DNA in Thai population and to characterize of the HPV genotypes in Thai patients with anogenital warts. Cervical swab and urine sample of 116 women and 100 men were collected before the Pap smear test. The histological examination of women can classified into 4 group: normal cytology in 52, ASCUS in 9, LSIL in 24, and HSIL in 31. In male patients, there were 45 heterosexual males who visited hospital for health check-up and 55 were documented as homosexuals or MSM. HPV DNA was genotyping by electrochemical DNA chip and PCR sequencing showed HPV16 was the most prevalence in this study. The HPV detection rate was generally lower in urine samples compared with cervical samples. There was good agreement for detection of carcinogenic HPV from female cervical samples between the DNA chip and PCR/sequencing, with 88.8% agreement. In male urine samples, the level of agreement was higher in heterosexuals compared with homosexuals. Moreover, the 164 pair of urine and cervical specimens were tested with Genoarray assay. The result showed overall concordance percentage for HPV detection was 65.2%. In addition, the comparison of 101 self-collected vaginal and physician-collected cervical swabs of known cytology was performed by DNA chip assay.? The result showed the concordance was relatively high between self-collected and physician-collected samples. The most common HPV genotype detected was HPV 51. Also, 58 cervicovaginal samples were tested for HPV genotypes using four methods in parallel: nested-PCR followed by conventional sequencing, INNO-LiPA, DNA chip, and NGS. These findings show that 7 HPV genotypes (16, 18, 31, 33, 45, 56, and 58) were identified by all four methods. Nineteen HPV genotypes were detected by NGS, but not by nested-PCR, INNO-LiPA, or DNA chip. This findings further showed the alternative method to detected HPV genotyping. Finally, the study was investigate HPV-associated anogenital warts in the Thai population and whether genotypes found are represented in the vaccine. A total of 206 anogenital swab samples were analyzed by PCR/sequencing. HPV positive was identified in 88.3% (182/206) of the samples. The majority of HPV (75.2%) were low-risk genotypes HPV6 and HPV11. This finding conclusion, this study demonstrated urine and self-collected swab is a promising technique for HPV screening. NGS may serve as an alternative for diagnostic HPV genotyping in certain situations. Moreover, quadrivalent vaccine could potentially prevent the genital warts in the Thai population.

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Number of External Anogenital Warts is Associated with the Occurrence of Abnormal Cervical Cytology

Cited by 4 publications

References 19 publications

Human Papillomavirus in Thai Women and Men with Anogenital Warts

Human Papillomavirus in Thai Women and Men with Anogenital Warts

Genital siğili olan kadınlarda servikal HPV ve servikal smear sonuçlarının karşılaştırılması

Assessment?of?human?papillomavirus?detection?using?different?methods?and?clinical?samples

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