Numeric Investigation of Brain Tumor Influence on the Current Distributions During Transcranial Direct Current Stimulation

Abstract

This study constructed a series of high-resolution realistic human-head models with brain tumors, and numerically investigated the influence of brain tumor's location and grade on the current distributions, under different electrode montages during tDCS. The threshold area and the peak current density were also derived and analyzed in the region of interest. The simulation result showed that it is safe to apply tDCS on the patients with brain tumors to treat their neuropsychiatric conditions and cancer pain caused by the tumor; although considerable changes of the current distributions are induced by the presence of a brain tumor. In addition, several observations on the global and local influences of tumor grade and possible edema have been made as well. These findings should be helpful for researchers and clinical doctors to treat patients with brain tumors. This study is also the first numerical study to fill in the gap of tDCS applications on the patients with brain tumors.

Automated detection of glioblastoma tumor in brain magnetic imaging using ANFIS classifier

“…Table shows the performance comparisons of the proposed method with conventional methodologies as Ahmad Chaddad (), Selvaraj and Dhanasekaran (), and Shanthakumar and Ganesh kumar () on Cancer Imaging Archive Dataset. Table shows the performance comparisons of the proposed method with conventional methodologies as Bo Song et al (), and Guang Yang et al (), on BRATS Dataset.…”

Reduction of intratumoral brain perfusion by noninvasive transcranial electrical stimulation

“…These include, for example, lack of smooth muscle cells in the walls, impaired shunts, and higher intercapillary distance in the context of an overall irregular microvascular architecture ( 3 , 27 ). In addition, the high conductivity of tumors as compared with healthy brain tissues ( 28 ), partly due to the abundance of vessels ( 27 ), might result in a greater current density inside the tumor. Other mechanisms, such as a possible tES effect on nitric oxide (NO) synthase, cannot be excluded, considering that electrical stimulation has been shown to modify (i.e., increase) NO synthase activity in animal models with consequent increase in tumor blood flow ( 29 ).…”

Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities

“…Accurate selection of patients on the basis of the localisation of the lesion respect to the target brain area (i.e., lesion not in the immediate proximity of the target region) would be of extreme importance along with the adoption of personalised stimulation protocols. Indeed, current flow across the brain can be accurately modelled and predicted when considering all the cranial compartments, the tumour mass and/or surgical cavity as well as metallic clips to obtain a personalised image-guided stimulation ( [96] , Fig. 4 A).…”