The need for building protection against blast loads is a crucial issue nowadays due to the escalating threat of terrorist attacks, which affect people’s lives and critical structures. Consequently, design of protective panels to segregate building façades from the effect of a nearby explosion is required. Such design mainly depends on the ability of protective panels to mitigate and diffract the blast wave before reaching building façades. Five protective panel models with different designs, referred to as the Combined Protection System (CPS), are introduced in this paper. The main objective of this research was to achieve a design that could sustain a blast load with minimum plastic deformations. The introduced CPS designs included two steel plates linked by connector plates. The CPS dimensions were 3 m × 3 m × 0.35 m, representing length, width, and height, respectively. After that, the successful panel design was supported by placing these panels onto a masonry wall in different configurations. The protective panels were tested against 50 kg of trinitrotoluene (TNT) with a standoff distance of one meter. The final run of the optimum model was carried out using a blast load equivalent to 500 kg of TNT. The air–structure interactions were simulated using finite element analysis software called “ANSYS AUTODYN”, where the deformation of the panel was the governing parameter to evaluate the behavior of different designs. The analysis showed minimum deformation of the CPS design with vertical and horizontal connecting plates in a masonry wall distanced at 500 mm from the panel. However, the other designs showed promising results, which could make them suitable for critical structural protection on different scales.