Numerical analysis of the influence of nucleus pulposus removal on the biomechanical behavior of a lumbar motion segment

Huang, Juying; H, Yan; Jian, Fengzeng; Wang, Xingwen; Li, Haiyun

doi:10.1080/10255842.2014.921815

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…Simulations showed that the effect of nucleotomy on disc joint mechanics depended on whether single or multi-loading modalities were considered. Under compression-or bending-only loading, nucleotomy decreased stiffness, agreeing with previous experimental and computational studies [2,3,5,6,32,39]. However, dual loading, such as compression combined with bending, resulted in an increase in bending stiffness, suggesting that the disc is more resistant to bending after nucleotomy.…”

Section: Discussionsupporting

confidence: 88%

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Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics

Yang

et al. 2019

Journal of Biomechanical Engineering

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Aging and degeneration of the intervertebral disk are noted by changes in tissue composition and geometry, including a decrease in nucleus pulposus (NP) area. The NP centroid is positioned slightly posterior of the disk's centroid, but the effect of NP size and location on disk joint mechanics is not well understood. We evaluated the effect of NP size and centroid location on disk joint mechanics under dual-loading modalities (i.e., compression in combination with axial rotation or bending). A finite element model (FEM) was developed to vary the relative NP area (NP:Disk area ratio range = 0.21–0.60). We also evaluated the effect of NP position by shifting the NP centroid anteriorly and posteriorly. Our results showed that compressive stiffness and average first principal strains increased with NP size. Under axial compression, stresses are distributed from the NP to the annulus, and stresses were redistributed toward the NP with axial rotation. Moreover, peak stresses were greater for disks with a smaller NP area. NP centroid location had a greater impact on intradiscal pressure during flexion and extension, where peak pressures in the posterior annulus under extension was greater for disks with a more posteriorly situated NP. In conclusion, the findings from this study highlight the importance of closely mimicking NP size and location in computational models that aim to understand stress/strain distribution during complex loading and for developing repair strategies that aim to recapitulate the mechanical behavior of healthy disks.

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Section: Discussionsupporting

confidence: 88%

“…Nucleotomy decreases disc joint stiffness in torsion, bending, and shear, resulting in an increase in range of motion and contact forces at the facet joints [2,3]. Internally, nucleotomy decreases intradiscal pressure under compression, resulting in inward bulging of the inner AF and greater maximum AF strains [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics

Yang

et al. 2019

Journal of Biomechanical Engineering

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“…As shown in Figure 2, the mean NP pressure and vertical displacement at the L4-L5 segment under axial compression forces of 300, 400, 500, 1,000, 1,600 and 2000 N was within the range of experimental data (Huang et al, 2015;Zeng et al, 2017;Bashkuev et al, 2018). The maximal AF stress under an axial compression of 300, 500, 1,000 and 2000 N was also in agreement with previous studies (Gay et al, 2006;Przybyla et al, 2006;Actis et al, 2017).…”

Section: Validation Of the Intact And Surgical Lumbar Femsupporting

confidence: 89%

Biomechanical evaluation of a novel intervertebral disc repair technique for large box-shaped ruptures

Nie

Huang

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: The purpose of this study was to analyze the feasibility of repairing a ruptured intervertebral disc using a patch secured to the inner surface of the annulus fibrosus (AF). Different material properties and geometries for the patch were evaluated.Methods: Using finite element analysis, this study created a large box-shaped rupture in the posterior-lateral region of the AF and then repaired it with a circular and square inner patch. The elastic modulus of the patches ranged from 1 to 50 MPa to determine the effect on the nucleus pulposus (NP) pressure, vertical displacement, disc bulge, AF stress, segmental range of motion (ROM), patch stress, and suture stress. The results were compared against the intact spine to determine the most suitable shape and properties for the repair patch.Results: The intervertebral height and ROM of the repaired lumbar spine was similar to the intact spine and was independent of the patch material properties and geometry. The patches with a modulus of 2–3 MPa resulted in an NP pressure and AF stresses closest to the healthy disc, and produced minimal contact pressure on the cleft surfaces and minimal stress on the suture and patch of all models. Circular patches caused lower NP pressure, AF stress and patch stress than the square patch, but also caused greater stress on the suture.Conclusion: A circular patch with an elastic modulus of 2–3 MPa secured to the inner region of the ruptured annulus fibrosus was able to immediately close the rupture and maintain an NP pressure and AF stress similar to the intact intervertebral disc. This patch had the lowest risk of complications and produced the greatest restorative effect of all patches simulated in this study.

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“…e size of the intervertebral foramen is closely related to the normal physiological morphology of spinal nerves and blood vessels, and some studies have shown that intervertebral disc degeneration is closely related to the height and area of the intervertebral foramen [19][20][21][22]. In this study, we analyzed the stress changes of the degenerative L4-5 intervertebral disc during pushing to a height of 0-10 cm and also analyzed the height and area of intervertebral foramen in these biomechanical environments.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Finite Element Analysis of L4-5 Degenerative Lumbar Disc Traction under Different Pushing Heights

Ding

Liao

Yan

et al. 2021

Journal of Healthcare Engineering

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Objective. To study and analyze the changes of intervertebral foramen height and area of the degenerative L4-5 intervertebral disc under different pushing heights by the finite element method. Methods. CT and MRI images of T12-S1 segments were obtained from a healthy volunteer who met the inclusion criteria. A DR machine was used to capture images of the lumbar lateral section before and after simultaneous pushing of the L4 and L5 spinous processes by manipulation called Daogaijinbei, and the measurement showed that the displacement changes of L4 and L5 were both approximately 10 cm, so the pushing height was set at 0–10 cm. A three-dimensional finite element model of the entire normal lumbar spine was established using Mimics 16.0, Geomagic Studio 2014, Hypermesh 13.0, MSC.Patran 2012, and so on. The disc height and nucleus area of the lumbar disc of the normal entire lumbar disc model were adjusted to establish models of the L4-5 disc with mild, moderate, and severe degeneration. Changes of disc height and area of the L4-5 degenerative intervertebral disc under different pushing heights were calculated. Results. The size of the L4-5 intervertebral foramen was analyzed from the height and area of the intervertebral foramen, and the results showed the following: (1) as for the normal lumbar disc and a lumbar of the L4-5 disc with mild and moderate degeneration, the height of the L4-5 intervertebral foramen and its area both increased during pushing between 0 and 8 cm. After the pushing height reached 8 cm, the height and area of the L4-5 intervertebral foramen gradually became stable; (2) as for the L4-5 disc with severe degeneration, during the process of pushing, the height and area of the L4-5 intervertebral foramen increased slightly, but this change was not obvious. Conclusions. After the spinal manipulation, the sizes of the L4-5 intervertebral foramen of the L4-5 disc with mild and moderate degeneration were significantly larger than those before pushing; in contrast, the size of L4-5 intervertebral foramen of the L4-5 disc with severe lumbar degeneration was not significantly changed.

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Numerical analysis of the influence of nucleus pulposus removal on the biomechanical behavior of a lumbar motion segment

Cited by 16 publications

References 27 publications

Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics

Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics

Biomechanical evaluation of a novel intervertebral disc repair technique for large box-shaped ruptures

Three-Dimensional Finite Element Analysis of L4-5 Degenerative Lumbar Disc Traction under Different Pushing Heights

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