Numerical analysis of the strain distribution in skin domes formed upon the application of hypobaric pressure

Sebastia‐Saez, Daniel; Benaouda, Faiza; Lim, Chui Hua; Lian, Guoping; Jones, Stuart A.; Chen, Tao; Cui, Liang

doi:10.1111/srt.13047

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…A complete description of the FEM model used to describe the skin biomechanics can be consulted in ref. 53 . The boundary conditions are as described in Fig.…”

Section: Methodsmentioning

confidence: 99%

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Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch

Benaouda

Inacio

Lim

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Significance Needleless delivery into the skin would overcome a major barrier to efficient clinical utilization of advanced therapies such as nanomaterials and macromolecules. This study demonstrates that controlled skin stretching (in porcine, rat, and mouse models) using a patch comprising a hypobaric chamber, to open the skin appendages, can increase the permeability of the tissue and provide a means to enable direct delivery of advanced therapies directly into the skin without the use of a needle or injection system. This technology can facilitate the self-administration of therapeutics including vaccines, RNA, and antigens, thus improving the translation of these products into effective clinical use.

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“…A complete description of the FEM model used to describe the skin biomechanics can be consulted in ref. 53 . The boundary conditions are as described in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…The thickness of the glass chamber is not considered. The model assumes no initial compression on the skin membrane caused by the positioning of the glass chamber ( 53 ). The lateral boundaries are fixed to mimic the effect of the pins that attach the skin to the board.…”

Section: Methodsmentioning

confidence: 99%

Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch

Benaouda

Inacio

Lim

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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“…The application of hypobaric pressure on the skin surface results in the formation of a dome, the stress-strain characteristics of which have been previously reported using a validated static simulation model [28]. A variation of the reported hyperelastic skin mechanical deformation simulation set-up including the follicular gaps was developed in COMSOL Multiphysics 5.5.…”

Section: Fem Modelling Of the Skin Mechanicsmentioning

confidence: 97%

“…Free boundaries were used on the bottom boundary and inside the follicular gaps. The one-term Ogden hyperelastic constitutive equation was used where denotes stress, lambda denotes stretch ratio, and = 0.03 MPa and = 13.57 are constants which are fitted from experimental skin tensile tests on porcine skin samples [28].…”

Section: Fem Modelling Of the Skin Mechanicsmentioning

confidence: 99%

In-Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device

et al. 2022

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Objectives To develop a simulation model to explore the interplay between mechanical stretch and diffusion of large molecules into the skin under locally applied hypobaric pressure, a novel penetration enhancement method. Methods Finite element method was used to model the skin mechanical deformation and molecular diffusion processes, with validation against in-vitro transdermal permeation experiments. Simulations and experimental data were used together to investigate the transdermal permeation of large molecules under local hypobaric pressure. Results Mechanical simulations resulted in skin stretching and thinning (20%–26% hair follicle diameter increase, and 21%–27% skin thickness reduction). Concentration of dextrans in the stratum corneum was below detection limit with and without hypobaric pressure. Concentrations in viable epidermis and dermis were not affected by hypobaric pressure (approximately 2 μg $$\bullet$$ ∙ cm−2). Permeation into the receptor fluid was substantially enhanced from below the detection limit at atmospheric pressure to up to 6 μg $$\bullet$$ ∙ cm−2 under hypobaric pressure. The in-silico simulations compared satisfactorily with the experimental results at atmospheric conditions. Under hypobaric pressure, satisfactory comparison was attained when the diffusion coefficients of dextrans in the skin layers were increased from $$\sim$$ ∼ 10 μm2$$\bullet$$ ∙ s−1 to between 200–500 μm2$$\bullet$$ ∙ s−1. Conclusions Application of hypobaric pressure induces skin mechanical stretching and enlarges the hair follicle. This enlargement alone cannot satisfactorily explain the increased transdermal permeation into the receptor fluid under hypobaric pressure. The results from the in-silico simulations suggest that the application of hypobaric pressure increases diffusion in the skin, which leads to improved overall transdermal permeation.

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Tackling the challenges of developing microneedle-based electrochemical sensors

2022

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Numerical analysis of the strain distribution in skin domes formed upon the application of hypobaric pressure

Cited by 3 publications

References 39 publications

Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch

Needleless administration of advanced therapies into the skin via the appendages using a hypobaric patch

In-Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device

Tackling the challenges of developing microneedle-based electrochemical sensors

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