Tackling the challenges of developing microneedle-based electrochemical sensors

Abdullah, Hilmee; Phairatana, Tonghathai; Jeerapan, Itthipon

doi:10.1007/s00604-022-05510-3

Cited by 22 publications

(14 citation statements)

References 183 publications

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“…132 More details on the current development status and challenges in developing microneedle-based electrochemical sensors can be found in several recent reviews. 128,133…”

Section: Integration In Portable Low-cost Substratesmentioning

confidence: 99%

“…(5) Manufacturability, biocompatibility, stability of use, and cost considerations by incorporating criteria for material selection, large scale fabrication, and adaptability in early prototype development. The ability to adjust the design ‘on-the-fly’ and adapt protocol to address individual needs is essential, particularly for personalized bioelectronics 133 such as wearables, microneedle-based interstitial sensors, and e-tattoos. Biocompatibility, mechanical durability, and intrinsic conductivity are additional criteria that should be delivered to meet FDA requirements.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

“…132 More details on the current development status and challenges in developing microneedle-based electrochemical sensors can be found in several recent reviews. 128,133 Along with microneedle technologies, a large variety of carbon-based microelectrodes have been developed for monitoring neurotransmitters. The wide majority are carbon fiber microelectrodes used to detect neurotransmitters to understand their role and evaluate treatment of diseases such as cancer, Parkinson's, and Alzheimer's, 134 which destroy the tissue of the brain, impairing movement and memory.…”

Section: Carbon-based Wearable Microneedles and Implantable Microelec...mentioning

confidence: 99%

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Carbon-based electrochemical biosensors as diagnostic platforms for connected decentralized healthcare

2023

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“…132 More details on the current development status and challenges in developing microneedle-based electrochemical sensors can be found in several recent reviews. 128,133…”

Section: Integration In Portable Low-cost Substratesmentioning

confidence: 99%

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Section: Carbon-based Wearable Microneedles and Implantable Microelec...mentioning

confidence: 99%

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Carbon-based electrochemical biosensors as diagnostic platforms for connected decentralized healthcare

2023

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“…Microneedle sensors provide significant benefits, including painless insertion into the skin, being irritation free, and being a minimally-invasive effective means for accessing the ISF biomarker. [63][64] Therefore, the microneedle can be inserted into the epidermal surface to detect biomolecules and collected real-time diagnostic data. The microneedle was designed via electrodeposition of Au-MWCNTs onto the Au surface of the microneedles, the electropolymerization of the methylene blue (MB) to form a polymethylene blue (pMB) mediator layer, and functionalized with LOx (Figure 2I).…”

Section: Technological Timeline Of Wearable Lactate Bioelectronicsmentioning

confidence: 99%

“…Also, in 2019, a pain‐free microneedle‐based biosensor was developed for the simultaneous monitoring of lactate in interstitial fluid (ISF). Microneedle sensors provide significant benefits, including painless insertion into the skin, being irritation free, and being a minimally‐invasive effective means for accessing the ISF biomarker [63–64] . Therefore, the microneedle can be inserted into the epidermal surface to detect biomolecules and collected real‐time diagnostic data.…”

Section: Technological Timeline Of Wearable Lactate Bioelectronicsmentioning

confidence: 99%

Wearable Electrodes for Lactate: Applications in Enzyme‐Based Sensors and Energy Biodevices

et al. 2023

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Wearable bioelectronics is a promising next-generation technology for its versatility in personalized applications. Measuring lactate is one of the growing trends in wearable biosensing research. To achieve this goal, enzymes capable of catalyzing reactions involving lactate must be coupled with bioelectrode components, creating a variety of biodevices such as biosensors, biofuel cells, and other devices harvesting energy from wearers. This review provides a brief history of noninvasive and minimally invasive enzyme-based lactate biosensors and energy biodevices. We introduce key principles of lactate oxidase and lactate dehydrogenase, together with immobilization strategies for efficient electrical contacts between redox enzymes and electrode supports. Additionally, we discuss recent examples of advanced wearable enzymatic lactate sensors and elaborate on a collection of self-powered wearable energy biodevices (e. g., biofuel cells, triboelectric nanogenerators, and piezoelectric devices). Lastly, we finish this review with discussions on challenges in developing lactate bioelectronics and provide our outlook on the prospects and future directions of this compelling technology.

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Engineering the Functional Expansion of Microneedles

Yang,

Xu,

Zhu

et al. 2024

Advanced Materials

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Microneedles (MNs), composed of an array of micro‐sized needles and a supporting base, have transcended their initial use to replace hypodermic needles in drug delivery and fluid collection, advancing toward multifunctional platforms. In this review, four major areas are summarized in interdisciplinary engineering approaches combined with MNs technology. First, electronics engineering, the most extensively researched field, enables applications in biomonitoring, electrical stimulation, and closed‐loop theranostics through the generation, transmission, and transformation of electrical signals. Second, in electromagnetic engineering, the responsiveness of electromagnetic induction offers prospects for remote and programmable therapeutic applications. Third, photonic engineering endows MNs with novel functionalities, such as waveguiding and photonic manipulation to enhance optical therapeutic capabilities and facilitate the visualization of disease progression and treatment processes. Lastly, it reviewed the role of mechanical engineering in conferring shape adaptability and programmable motion features necessary for various MNs applications. This review focuses on the functionalities that emerge from the intersection of MNs with complementary engineering technologies, aiming to inspire further research and innovation in microneedle technology for biomedical applications.

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Tackling the challenges of developing microneedle-based electrochemical sensors

Cited by 22 publications

References 183 publications

Carbon-based electrochemical biosensors as diagnostic platforms for connected decentralized healthcare

Carbon-based electrochemical biosensors as diagnostic platforms for connected decentralized healthcare

Wearable Electrodes for Lactate: Applications in Enzyme‐Based Sensors and Energy Biodevices

Engineering the Functional Expansion of Microneedles

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