This study aims to quantify and assess qualitatively the impact of modeling simplifications used to represent inertial and aerodynamic loads on the stresses and structural deformations of a centrifugal compressor in operation. The research object is the compressor of the high-pressure line of the DGEN 380 bypass turbine engine. Based on the virtual dynamometer WESTT CS/BV, the gas-dynamic parameters at the entrance to the centrifugal compressor and after the stage are determined. These values were used as initial parameters for numerical flow analysis. As part of the numerical strength analyses, a series of several load configurations were carried out: spin only, spin and inlet pressure normally applied on the working surface of the rotor blade, spin and outlet pressure normally applied on the working surface of the rotor blade, and one-way fluid–structure interaction analysis taking into account the aerodynamic loads with and without spinning. Based on the simulations, the level of similarity of a given load configuration with the last analysis, adopted as the reference, was determined. It was observed that in terms of the stress state, the rotational analysis taking into account the pressure on both sides of the blade gives satisfactory results, but the strain values are overestimated. The results obtained and the method of evaluation of compressor results can be used in research in the area of aviation, automotive, and refrigeration industries.