Using an idealized model it is shown that, to minimize errors in double-spiked isotopic analyses, spike mass numbers should alternate with normal. The comprehensive error analysis which follows assumes that the individual ion currents are the independent variates for statistical purposes: errors in these are obtained by combining (i) a coefficient of variation e p due to fluctuations in ion emission with (ii) a resistor noise index eR and (iii) a shot noise index es: the noise indices are the ratios [error due to noise]/[error (i) due to emission fluctuation] for the largest ion beam in the spectrum. Methods of computing error multipliers (operating on e,,) from eR, es and the isotopic abundances, are developed. For