Diseases and pests are important factors in vegetable cultivation; they not only affect the growth and appearance of vegetables but also affect the yield and quality. The disease and pest control of vegetables is dominated by chemical sprays, for now. As a result, the excessive use of pesticides has been a crucial factor of pesticides’ non-point source pollution, and it is also the main cause of excessive pesticide residues in vegetables. Therefore, the design of efficient plant protection machinery and technology has become an urgent demand in order to ensure the quality and safety of vegetables. In this review, the machinery and technologies for vegetable protection are introduced from the aspects of chemical control and physical control. In the aspect of chemical control, handheld sprayers, self-propelled or track sprayers, fixed-pipe spray systems, vertical and horizontal boom sprayers, unmanned aerial vehicles (UAVs) and vegetable seed treatment techniques are introduced. In the aspect of physical control, soil physical disinfection, pest trapping technologies and ozone sterilizers are introduced. Finally, the existing problems and perspectives of pesticide application sprayers and physical control equipment for vegetables are summarized. This paper can provide references for vegetable growers and researchers.