small specimens as single cells, [2] single neurons, [3][4][5] and myofibers, [6] and even functional investigation of such samples. [7] Although the ultimate limit to spatial resolution in MRM is the diffusion of water within the finite measuring time, the practical limit is the achievable signal-tonoise ratio (SNR) per unit voxel in a given data acquisition time. [1,8] MRM is performed at very high B 0 with compact radiofrequency coils (called probes) typically operating both in transmission and reception modes. The probes should be made as close-fitting as possible for a given sample to maximize the SNR and, therefore, attainable image spatial resolution. [8] As the noise is generated by both the probe and the sample, reducing the probe losses and the electric-field-mediated coil-sample interactions is very desirable. [9] Cooling the probe down to cryogenic temperatures allows operation in a mode in which the noise is dominated by the sample. Several authors reported an approximately twofold increase in SNR when studying biological samples compared to using conventional copper coils. [10,11] The disadvantage of all cryogenic probes is that they are much more difficult to fabricate and provide limited access to the sample as well as a lower filling factor.The spatial resolution and signal-to-noise ratio (SNR) attainable in magnetic resonance microscopy (MRM) are limited by intrinsic probe losses and probe-sample interactions. In this work, the possibility to exceed the SNR of a standard solenoid coil by more than a factor-of-two is demonstrated theoretically and experimentally. This improvement is achieved by exciting the first transverse electric mode of a low-loss ceramic resonator instead of using the quasi-static field of the metal-wire solenoid coil. Based on theoretical considerations, a new probe for microscopy at 17 T is developed as a dielectric ring resonator made of ferroelectric/dielectric low-loss composite ceramics precisely tunable via temperature control. Besides the twofold increase in SNR, compared with the solenoid probe, the proposed ceramic probe does not cause static-field inhomogeneity and related image distortion.
Ceramics for Improved Microscopy