Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia

Raouf, Izaz; Gas, Pacific; Kim, Heung-Soo

doi:10.3390/s21165545

Cited by 18 publications

(6 citation statements)

References 68 publications

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“…All of the utilized properties of different materials considered in the current study are mentioned in Table 1 . Nanofluid’s effective properties can be calculated according to the formulas mentioned in reference [ 48 ] and mentioned in Table 1 as well.…”

Section: Methodsmentioning

confidence: 99%

Numerical study of magnetic hyperthermia ablation of breast tumor on an anatomically realistic breast phantom

Rahpeima

Lin

2022

PLoS ONE

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Magnetic fluid hyperthermia (MFH) is a novel reliable technique with excellent potential for thermal therapies and treating breast tumours. This method involves injecting a magnetic nanofluid into the tumour and applying an external AC magnetic field to induce heat in the magnetic nanoparticles (MNPs) and raise the tumour temperature to ablation temperature ranges. Because of the complexity of considering and coupling all different physics involves in this phenomenon and also due to the intricacy of a thorough FEM numerical study, few FEM-based studies address the entire MFH process as similar to reality as possible. The current study investigates a FEM-based three-dimensional numerical simulation of MFH of breast tumours as a multi-physics problem. An anatomically realistic breast phantom (ARBP) is considered, some magnetic nanofluid is injected inside the tumour, and the diffusion phenomenon is simulated. Then, the amount of heat generated in the MNP-saturated tumour area due to an external AC magnetic field is simulated. In the end, the fraction of tumour tissue necrotized by this temperature rise is evaluated. The study’s results demonstrate that by injecting nanofluid and utilizing seven circular copper windings with each coil carrying 400 A current with a frequency of 400 kHz for generating the external AC magnetic field, the temperature in tumour tissue can be raised to a maximum of about 51.4°C, which leads to necrosis of entire tumour tissue after 30 minutes of electromagnetic field (EMF) exposure. This numerical platform can depict all four various physics involved in the MFH of breast tumours by numerically solving all different equation sets coupled together with high precision. Thus, the proposed model can be utilized by clinicians as a reliable tool for predicting and identifying the approximate amount of temperature rise and the necrotic fraction of breast tumour, which can be very useful to opt for the best MFH therapeutic procedure and conditions based on various patients. In future works, this numerical platform’s results should be compared with experimental in-vivo results to improve and modify this platform in order to be ready for clinical applications.

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Section: Methodsmentioning

confidence: 99%

Numerical study of magnetic hyperthermia ablation of breast tumor on an anatomically realistic breast phantom

Rahpeima

Lin

2022

PLoS ONE

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“…The co‐treatment of the patients with chemo‐radiotherapy and smart drug delivery systems efficiently augmented cytotoxicity against malignant cells, where surgical implantation of the NF mesh into the cancer site could impede cancer relapse. In this regard, one of the most promising solutions in this area is the use of multidrug‐loaded NFs, which can reduce the dosage used while still increasing the effectiveness of chemotherapy (Beola et al, 2021; Liu et al, 2022; Raouf et al, 2021). Nanoengineered implants can then be used to enhance these systems by ensuring controlled and stable release, lowering side effects and boosting medication bioavailability at the target site (Kobayashi, 2011; Rodrigues et al, 2020; Stephen & Zhang, 2021).…”

Section: Smart Chemo‐delivery Systemsmentioning

confidence: 99%

Implantable smart hyperthermia nanofibers for cancer therapy: Challenges and opportunities

Valizadeh

Asghari

Abbaspoor

et al. 2023

WIREs Nanomed Nanobiotechnol

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Nanofibers (NFs) with practical drug‐loading capacities, high stability, and controllable release have caught the attention of investigators due to their potential applications in on‐demand drug delivery devices. Developing novel and efficient multidisciplinary management of locoregional cancer treatment through the design of smart NF‐based systems integrated with combined chemotherapy and hyperthermia could provide stronger therapeutic advantages. On the other hand, implanting directly at the tumor area is a remarkable benefit of hyperthermia NF‐based drug delivery approaches. Hence, implantable smart hyperthermia NFs might be very hopeful for tumor treatment in the future and provide new avenues for developing highly efficient localized drug delivery systems. Indeed, features of the smart NFs lead to the construction of a reversibly flexible nanostructure that enables hyperthermia and facile switchable release of antitumor agents to eradicate cancer cells. Accordingly, this study covers recent updates on applications of implantable smart hyperthermia NFs regarding their current scope and future outlook.This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants

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“…When a ferrofluid solution is evaluated on different parameters and the temperature distribution of the system is calculated in space and time, the optimum therapeutic conditions can be found. 140 Regarding MRI, research has shown that IONPs contrast agents are less toxic than other materials such as gadoliniumbased contrast agents. Nevertheless, biocompatibility, biodistribution, and pharmacokinetics should be studied for the future applications of IONPs in clinical stages.…”

Section: Applications Of Ferrofluidsmentioning

confidence: 99%

“…The development of numerical models that correlate the magnetic NP hyperthermia parameters to the thermal response is relevant. When a ferrofluid solution is evaluated on different parameters and the temperature distribution of the system is calculated in space and time, the optimum therapeutic conditions can be found …”

Section: Applications Of Ferrofluidsmentioning

confidence: 99%

Approaches on Ferrofluid Synthesis and Applications: Current Status and Future Perspectives

et al. 2022

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Ferrofluids are colloidal suspensions of iron oxide nanoparticles (IONPs) within aqueous or nonaqueous liquids that exhibit strong magnetic properties. These magnetic properties allow ferrofluids to be manipulated and controlled when exposed to magnetic fields. This review aims to provide the current scope and research opportunities regarding the methods of synthesis of nanoparticles, surfactants, and carrier liquids for ferrofluid production, along with the rheology and applications of ferrofluids within the fields of medicine, water treatment, and mechanical engineering. A ferrofluid is composed of IONPs, a surfactant that coats the magnetic IONPs to prevent agglomeration, and a carrier liquid that suspends the IONPs. Coprecipitation and thermal decomposition are the main methods used for the synthesis of IONPs. Despite the fact that thermal decomposition provides precise control on the nanoparticle size, coprecipitation is the most used method, even when the oxidation of iron can occur. This oxidation alters the ratio of maghemite/magnetite, influencing the magnetic properties of ferrofluids. Strategies to overcome iron oxidation have been proposed, such as the use of an inert atmosphere, adjusting the Fe(II) and Fe(III) ratio to 1:2, and the exploration of other metals with the oxidation state +2. Surfactants and carrier liquids are chosen according to the ferrofluid application to ensure stability. Hence, a compatible carrier liquid (polar or nonpolar) is selected, and then, a surfactant, mainly a polymer, is embedded in the IONPs, providing a steric barrier. Due to the variety of surfactants and carrier liquids, the rheological properties of ferrofluids are an important response variable evaluated when synthesizing ferrofluids. There are many reported applications of ferrofluids, including biosensing, medical imaging, medicinal therapy, magnetic nanoemulsions, and magnetic impedance. Other applications include water treatment, energy harvesting and transfer, and vibration control. To progress from synthesis to applications, research is still ongoing to ensure control of the ferrofluids’ properties.

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Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia

Cited by 18 publications

References 68 publications

Numerical study of magnetic hyperthermia ablation of breast tumor on an anatomically realistic breast phantom

Numerical study of magnetic hyperthermia ablation of breast tumor on an anatomically realistic breast phantom

Implantable smart hyperthermia nanofibers for cancer therapy: Challenges and opportunities

Approaches on Ferrofluid Synthesis and Applications: Current Status and Future Perspectives

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