Numerical investigation of the effects of shear waves in transcranial photoacoustic tomography with a planar geometry

Schoonover, Robert W.; Wang, Lihong V.; Anastasio, Mark A.

doi:10.1117/1.jbo.17.6.061215

Cited by 25 publications

(21 citation statements)

References 28 publications

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“…The effects of shear wave propagation and attenuation are both strongly dependent on the thickness of the skull. In this work, the average thickness of the skull was 3 mm and the distortions to the PA signal due to absorption and propagating shear waves were expected 24 to be of second-order effect as compared to the distortions due to the variations in the SOS and density. For adult human skulls, where the skull can be ∼7 mm thick, the relative importance of these effects in transcranial PAT remains to be investigated.…”

Section: Summary and Discussionmentioning

confidence: 99%

“…To date, the manner in which shear waves propagating in the skull affect PAT has only been investigated quantitatively for stratified planar media and planar detection surfaces 24,44 via computer-simulation studies. In that case, the effects were observed only in certain highspatial resolution components of the imaged object.…”

Section: Summary and Discussionmentioning

confidence: 99%

“…5. It should be noted that the density and SOS heterogeneities both have stronger effects and cause more acoustic energy to be reflected back into skull than do the shear wave mode-conversion or attenuation for acoustic plane-wave components incident on the skull surface at small (∼30 deg or less) angles 24 from the surface normal.…”

Section: Imaging Physicsmentioning

confidence: 99%

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Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang

2012

J. Biomed. Opt

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Abstract. A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.

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Section: Summary and Discussionmentioning

confidence: 99%

Section: Summary and Discussionmentioning

confidence: 99%

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Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang

2012

J. Biomed. Opt

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“…Accordingly, we employed a 2D imaging model in the experimental study, and all the reconstructions were performed on a grid of 512 × 512 pixels with a pitch of 0.5 mm. The effects of shear wave propagation in the acrylic cylinder were neglected, which we expected to be of secondorder importance compared to wavefield perturbations that arise from inhomogeneties in the SOS and density distributions [48].…”

Section: E Studies Utilizing Experimental Datamentioning

confidence: 99%

Full-Wave Iterative Image Reconstruction in Photoacoustic Tomography With Acoustically Inhomogeneous Media

Huang

Wang

Nie

et al. 2013

IEEE Trans. Med. Imaging

237

244

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Existing approaches to image reconstruction in photoacoustic computed tomography (PACT) with acoustically heterogeneous media are limited to weakly varying media, are computationally burdensome, and/or cannot effectively mitigate the effects of measurement data incompleteness and noise. In this work, we develop and investigate a discrete imaging model for PACT that is based on the exact photoacoustic (PA) wave equation and facilitates the circumvention of these limitations. A key contribution of the work is the establishment of a procedure to implement a matched forward and backprojection operator pair associated with the discrete imaging model, which permits application of a wide-range of modern image reconstruction algorithms that can mitigate the effects of data incompleteness and noise. The forward and backprojection operators are based on the k-space pseudospectral method for computing numerical solutions to the PA wave equation in the time domain. The developed reconstruction methodology is investigated by use of both computer-simulated and experimental PACT measurement data.

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“…However, in cases in which the speed of sound and acoustic absorption within the tissue are spatially varying, the inverse problem becomes significantly more challenging. [8][9][10][11][12][13][14][15][16][17] In this paper, it is assumed that the acoustic inverse problem in QPAT is performed in an idealistic fashion. The data that are utilized in the numerical analysis are formed by using the true acoustic initial pressure distribution with noise added to it.…”

Section: Introductionmentioning

confidence: 99%

Quantitative photoacoustic tomography using illuminations from a single direction

et al. 2015

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Abstract. Quantitative photoacoustic tomography is an emerging imaging technique aimed at estimating optical parameters inside tissues from photoacoustic images, which are formed by combining optical information and ultrasonic propagation. This optical parameter estimation problem is ill-posed and needs to be approached within the framework of inverse problems. It has been shown that, in general, estimating the spatial distribution of more than one optical parameter is a nonunique problem unless more than one illumination pattern is used. Generally, this is overcome by illuminating the target from various directions. However, in some cases, for example when thick samples are investigated, illuminating the target from different directions may not be possible. In this work, the use of spatially modulated illumination patterns at one side of the target is investigated with simulations. The results show that the spatially modulated illumination patterns from a single direction could be used to provide multiple illuminations for quantitative photoacoustic tomography. Furthermore, the results show that the approach can be used to distinguish absorption and scattering inclusions located near the surface of the target. However, when compared to a full multidirection illumination setup, the approach cannot be used to image as deep inside tissues. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Numerical investigation of the effects of shear waves in transcranial photoacoustic tomography with a planar geometry

Cited by 25 publications

References 28 publications

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Full-Wave Iterative Image Reconstruction in Photoacoustic Tomography With Acoustically Inhomogeneous Media

Quantitative photoacoustic tomography using illuminations from a single direction

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