Numerical modeling of electrowetting transport processes for digital microfluidics

Clime, Liviu; Brassard, D.; Veres, Teodor

doi:10.1007/s10404-009-0491-9

Cited by 17 publications

(12 citation statements)

References 36 publications

(38 reference statements)

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“…61,63,64 The contact angle of the liquid with the surface was set to a value of about 56° by adjusting the solid-liquid interaction potential. No external force was applied to the liquid.…”

Section: Methodsmentioning

confidence: 99%

“…A more detailed description of the numerical simulations is available 20 elsewhere. 61 The protein and DNA immobilization assays were performed on plastic substrates (25 mm in width, 75 mm in length and 1 mm in height) that were fabricated from Zeonor 1060R (Zeon Chemicals, Louisville, KY) by an injection 25 molding process. Before the immobilization assays, the Zeonor slides were subjected to an ozone treatment for ~15 min using an Ozo 2vtt ozone generator (Ozomax, Shefford, QC).…”

Section: Methodsmentioning

confidence: 99%

“…The layout of the channels has thus been designed and optimized with the help of 3D numerical simulations based on the Lattice-Boltzmann method. [60][61][62] Fig. 4a shows the various 35 steps by which the liquid enters the spotting holes while Fig.…”

Section: Filling Of the Spotting Holes By Capillary Actionmentioning

confidence: 99%

“…This, in turn, increases the force exerted by the capillary action, which helps filling the spotting holes. 61 On the other hand, both simulations and experiments indicate that it takes 45 considerably longer to fill the spotting holes than the surrounding channels. Consequently, air bubbles are trapped if the liquid in the surrounding channel is not held in place until the hole is properly filled.…”

Section: Filling Of the Spotting Holes By Capillary Actionmentioning

confidence: 99%

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3D thermoplastic elastomer microfluidic devices for biological probe immobilization

Brassard

Clime

et al. 2011

Lab Chip

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Microfluidics has emerged as a valuable tool for the high-resolution patterning of biological probes on solid supports. Yet, its widespread adoption as a universal biological immobilization tool is still limited by several technical challenges, particularly for the patterning of isolated spots using three-dimensional (3D) channel networks. A key limitation arises from the difficulties to adapt the techniques and materials typically used in prototyping to low-cost mass-production. In this paper, we present the fabrication of thin thermoplastic elastomer membranes with microscopic through-holes using a hotembossing process that is compatible with high-throughput manufacturing. The membranes provide the basis for the fabrication of highly integrated 3D microfluidic devices with a footprint of only 1 Â 1 cm 2 . When placed on a solid support, the device allows for the immobilization of up to 96 different probes in the form of a 10 Â 10 array comprising isolated spots of 50 Â 50 mm 2 . The design of the channel network is optimized using 3D simulations based on the Lattice-Boltzmann method to promote capillary action as the sole force distributing the liquid in the device. Finally, we demonstrate the patterning of DNA and protein arrays on hard thermoplastic substrates yielding spots of excellent definition that prove to be highly specific in subsequent hybridization experiments.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Filling Of the Spotting Holes By Capillary Actionmentioning

confidence: 99%

Section: Filling Of the Spotting Holes By Capillary Actionmentioning

confidence: 99%

See 2 more Smart Citations

3D thermoplastic elastomer microfluidic devices for biological probe immobilization

Brassard

Clime

et al. 2011

Lab Chip

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“…For merging, several electrode arrays have to be operated simultaneously, in order to bring the two or more droplets in contact. In depth numerical modeling of electro-wetting transport is given by [12][13][14]. Electro-wetting has been performed in air [15], silicone oil [16].…”

Section: Electro Wettingmentioning

confidence: 99%

Digital Microfluidics: Techniques, Their Applications and Advantages

Agarwal¹

2013

J Bioeng Biomed Sci

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Digital Microfluidics is a recent advent of the miniaturization boom that can be witnessed over the couple of decades. The conventional techniques developed for continuous microfluidics cannot necessarily be used directly for application to digital microfluidics. This paper presents a brief overview of the techniques used for performing different operations in Digital Microfluidics namely Electro-wetting, Dielectrophoresis (DEP), Opto-electro-wetting (OEW), Thermo-capillary effect, Surface Acoustic Waves (SAW), etc.

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Digital Microfluidic Systems: Fundamentals, Configurations, Techniques, and Applications

Yafia

Emran

Najjaran

2018

Microfluidics: Fundamental, Devices and Applications

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Numerical modeling of electrowetting transport processes for digital microfluidics

Cited by 17 publications

References 36 publications

3D thermoplastic elastomer microfluidic devices for biological probe immobilization

3D thermoplastic elastomer microfluidic devices for biological probe immobilization

Digital Microfluidics: Techniques, Their Applications and Advantages

Digital Microfluidic Systems: Fundamentals, Configurations, Techniques, and Applications

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