This work shows the performance of LincoSim, a web-based virtual towing tank enabling automated and standardized calm water computational fluid dynamics (CFD) data sampling, extending previous published applications to the case of a high-speed hull. The calculations are performed for a 1:10 scale model of a 43 ft powerboat hull form in the Froude number range from 0.3 to 2.0. The counterpart physical model is the experimental fluid dynamics (EFD) campaign performed at the University of Naples Federico II, where the resistance, sinkage and trim data have been measured. The EFD/CFD data comparison is performed and shown with a discussion of the spotted differences. The average percentage differences between the EFD and CFD data for the whole speed range are 1.84, 6.87 and 6.94 for the resistance, dynamic trim, and sinkage, respectively. These results confirm the maturity of the standardized and automated CFD modeling for calm water hydrodynamic analysis included in LincoSim, even at very high Froude numbers. The wetted length of the keel and chine and the wetted surface are calculated from numerical data using the advanced post-processing. Finally, as a work in progress, we test a first comparison for the same hull of the EFD and CFD data, considering two seakeeping conditions for head waves at a given wavelength for two velocity conditions. Also, this kind of analysis confirms the tight correlation between the measured and computed outcomes. This synergic interplay of EFD and CFD can link the advantages of both methods to support hull design but also requires experiment planning and final data analysis to obtain physical parameters not easily measurable in laboratory, such as the wetted surface, wetted lengths, proper viscous contribution, and pressure distribution both in calm water and in waves.