It is discovered that the micro integral impeller’s NC programming is quite complex and that surface deformation and tool collision interference are easily caused by its torsional small channel, semi-closed construction, and complex free thin-wall surface. Furthermore, roughing has the longest processing time and the greatest quantity of material removal, making it easier to influence the next step in the processing process. Two machining techniques are suggested to address the NC roughing issue with this item. One tactic is to complete the impeller’s roughing by utilizing the benefits of a five-axis machine tool and the hierarchical parametric technique. The other is positioning five-axis roughing, which is roughing on a fixed five-axis region and is handled based on the flow path’s sub-area under the planned vector and area. The findings of the virtual simulation demonstrate that roughing in the five-axis fixed region may significantly increase machining efficiency and reduce machining time under the same machining circumstances. Lastly, tests are conducted to confirm the correctness of the virtual simulation model.