The submarine is a crucial component of marine strategic equipment known for their flexibility and excellent concealment. It is essential to ensure the safety of submarine navigation during the initial design stage, and maneuverability is one of the key performances for assessing its safety and motility. This paper is based on the CFD method to numerically study the maneuverability of the SUBOFF submarine. By predicting the straight-line navigation resistance of the submarine, the results agreed well with the test values, which verified the accuracy of the numerical method. In addition, two methods of static and dynamic prediction were used to solve the self-propulsion point based on the Body Force Method for the SUBOFF submarine with E1619 propeller, and ultimately the relative errors of the two methods of the propeller rotational speed and thrust were -1.56% and -4.54%, respectively. The performance parameters of the propeller thrust coefficient ΚT and torque coefficient ΚQ were also close to each other base on the two methods, and the relative errors were all within 3%. This paper provides a good foundation for the prediction of zigzag test, turning circle and other motions of the subsequent submarine, which is of great significance.