As an important component of large-scale extruder system for polymer material, Die-plate can be regarded as the final determinant for pelletization uniformity. Polymer melt was shaped in shaping channels and extruded from die-holes from Die-plate and then be diced. The design of shaping channels directly influences the uniformity for polymer-melt extrusion pressure and extrusion velocity of different die holes. In this paper, a three-dimensional flow model for polymer flow in Die-plate channel was presented, and then finite element simulation was used to analyze the distribution of extrusion velocity in each die-hole. Based on simulation result, a BP neural network model was applied to analyze the relationship between geometry factors of Die-plate, such as length of shaping channels, die hole extrusion velocity distribution, and extrusion uniformity. This optimization method can be used in the design of Die-plate to improve effect and quality of actual polymer production and processing.