Numerical simulation of transport and adhesion of thermogenic nano-carriers in microvessels

Yue, Kai; You, Yu; Yang, Chao; Niu, Yongjian; Zhang, Xinxin

doi:10.1039/d0sm01448f

Cited by 11 publications

(7 citation statements)

References 62 publications

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“…Although it has long been thought that drug nanocarriers will facilitate cancer therapeutics by directing drugs to solid tumors, nanomedicine development has not yet achieved promising clinical outcomes. Numerous reports indicate that virus-/inorganic nanoparticles-/organic nanoparticles-based nanocarriers could improve the efficacy and safety of anticancer drugs through potential targeting, mitigated drug release in non-target tissues, and pH-sensitive drug release in the tumor microenvironment (TME) [ 4 , 5 , 6 , 7 ]. Tumor vascular permeability and the enhanced permeability and retention (EPR) mechanism in macromolecular drug delivery to solid tumors have been reported as successful strategies for cancer therapeutics [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment

Sharifi

Cho

Ansariesfahani

et al. 2022

Cancers

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The enhanced permeability and retention (EPR) effect in cancer treatment is one of the key mechanisms that enables drug accumulation at the tumor site. However, despite a plethora of virus/inorganic/organic-based nanocarriers designed to rely on the EPR effect to effectively target tumors, most have failed in the clinic. It seems that the non-compliance of research activities with clinical trials, goals unrelated to the EPR effect, and lack of awareness of the impact of solid tumor structure and interactions on the performance of drug nanocarriers have intensified this dissatisfaction. As such, the asymmetric growth and structural complexity of solid tumors, physicochemical properties of drug nanocarriers, EPR analytical combination tools, and EPR description goals should be considered to improve EPR-based cancer therapeutics. This review provides valuable insights into the limitations of the EPR effect in therapeutic efficacy and reports crucial perspectives on how the EPR effect can be modulated to improve the therapeutic effects of nanomedicine.

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Section: Introductionmentioning

confidence: 99%

An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment

Sharifi

Cho

Ansariesfahani

et al. 2022

Cancers

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“…The particle adhesion at the temperature of 25°C was better than that at 39°C and reached the minimum at 43°C. Our previous simulation work 50 showed that an increase in temperature leads to an increase in the number of NPs attached to the vessel wall when the influence of temperature on the binding of the ligands on NPs to the receptors of endothelial cells is ignored. The reason is that the drag force acting on the particles and the Brownian movement of the particles change greatly with the increase in temperature, leading to a high probability of NP margination to the vessel wall for adhesion.…”

Section: Resultsmentioning

confidence: 99%

Experimental Investigation of Temperature Influence on Nanoparticle Adhesion in an Artificial Blood Vessel

Yue

Yang

You

et al. 2023

IJN

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Background A good understanding of the adhesion behaviors of the nanocarriers in microvessels in chemo-hyperthermia synergistic therapy is conducive to nanocarrier design for targeted drug delivery. Methods In this study, we constructed an artificial blood vessel system using gelatins with a complete endothelial monolayer formed on the inner vessel wall. The numbers of adhered NPs under different conditions were measured, as well as the interaction forces between the arginine–glycine–aspartic acid (RGD) ligands and endothelial cells. Results The experimental results on the adhesion of ligand–coated nanoparticles (NPs) with different sizes and morphologies in the blood vessel verified that the gelatin-based artificial vessel possessed good cytocompatibility and mechanical properties, which are suitable for the investigation on NP adhesion characteristics in microvessels. When the temperature deviated from 37 °C, an increase or decrease in temperature resulted in a decrease in the number of adhered NPs, but the margination probability of NP adhesion increased at high temperatures due to the enhanced Brownian movement and flow disturbance. It is found that the effect of cooling was less than that of heating according to the observed changes in cell morphology and a decrease in cell activity under the static and perfusion culture conditions within the temperature range of 25 °C–43 °C. Furthermore, the measurement results of change in the RGD ligand-cell interaction with temperature showed good agreement with those in the number of adhered NPs. Conclusion The Findings suggest that designing ligands that can bind to the receptor and are least susceptible to temperature variation can be an effective means to enhance drug retention.

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“…Droplet-based microfluidics has gained widespread attention among researchers for the past two decades, owing to its capability of precise control of minute volumes (Manga 1996;Adamson et al 2006;Baroud, Gallaire & Dangla 2010;Vladisavljević et al 2013;Nozaki et al 2021). Important to mention here is that the paradigm of droplet-based microfluidics has shown significant technical and research potential specifically due to its suitability in point-of-care diagnostics (Shamloo & Hassani-Gangaraj 2020), drug delivery (Yue et al 2020), analysing and screening of bio/chemical reaction products (Zheng & Ismagilov 2005) and many more related areas (Moon et al 2010;Santos et al 2016;Madadelahi, Ghazimirsaeed & Shamloo 2019). Researchers have explored several aspects of droplet behaviour such as droplet generation, breakup (Link et al 2004;Jullien et al 2009;Leshansky & Pismen 2009;Leshansky et al 2012;Hoang et al 2013) and merging/coalescence (Christopher et al 2009), in various microfluidic devices such as a T-junction, flow-focusing junction and co-flowing junction, to name a few.…”

Section: Introductionmentioning

confidence: 99%

“…Important to mention here is that the paradigm of droplet-based microfluidics has shown significant technical and research potential specifically due to its suitability in point-of-care diagnostics (Shamloo & Hassani-Gangaraj 2020), drug delivery (Yue et al. 2020), analysing and screening of bio/chemical reaction products (Zheng & Ismagilov 2005) and many more related areas (Moon et al. 2010; Santos et al.…”

Section: Introductionmentioning

confidence: 99%

Magnetofluidic-based controlled droplet breakup: effect of non-uniform force field

2022

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We report the breakup dynamics of a magnetically active (ferrofluid) droplet in a T-shaped Lab on a Chip (LOC) device under the modulation of a non-uniform magnetic field. We adhere to high-speed imaging modalities for the experimental quantification of the droplet splitting phenomenon, while the underlying phenomenon is supported by the numerical results in a qualitative manner as well. On reaching the T-junction divergence, the droplet engulfs the intersection fully and eventually deforms into the dumbbell-shaped form, making its bulges move towards the branches of the junction. We observe that the asymmetric distribution of the magnetic force lines, acting over the T-junction divergence, induces an accelerating motion to the left of the moving bulge (since the magnet is placed adjacent to the left branch). We show that the non-uniform force field gradient allows the formation of a hump-like structure inside the left moving bulge, which triggers the onset of augmented convection in its flow field. We reveal that this augmented internal convection developed in the left moving volume/bulge, on becoming coupled to the various involved time scales of the flow field, leads to the asymmetric splitting of the droplet into two sister droplets. Our analysis establishes that, at the critical strength of the applied forcing, as realized by the critical magnetic Bond number, the flow time scale becomes minimum at the left branch of the channel, leading to the formation of larger sized sister droplets therein. Inferences of the present analysis, which demonstrates a plausible means of independently controlling the size of the sister droplet by manoeuvring the applied force field gradient, will provide a potential solution for rapid droplet splitting, which typically finds significant importance in point-of-care diagnostics.

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Numerical simulation of transport and adhesion of thermogenic nano-carriers in microvessels

Abstract: Externally triggered thermogenic nanoparticles (NPs) are potential drug carriers and heating agents for drug delivery and hyperthermia. A good understanding of transport and adhesion behaviors of NPs in microvessels is...

Cited by 11 publications

References 62 publications

An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment

An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment

Experimental Investigation of Temperature Influence on Nanoparticle Adhesion in an Artificial Blood Vessel

Magnetofluidic-based controlled droplet breakup: effect of non-uniform force field

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