“…When the pressure and/or temperature changes from the thermodynamic equilibrium state in the hydrate stability zone to the instability zone due to climate change, sea-level variation, and involvement in gas exploitation (e.g., depressurization, thermal stimulation, CH4-CO2 replacement, and inhibitor injection), the gas hydrate dissociates into water and gas (Goto et al 2016;Horozal et al 2017;Kwon et al 2008;Ruppel and Kessler, 2017;Sultan et al 2004;Wallmann et al 2018;Waite et al 2009). This dissociation will lead to degradation of the mechanical properties (e.g., stiffness, strength, dilation) of the hydrate-bearing sediment (HBS), resulting in various disasters, such as submarine landslides, differential subsidence of the seafloor, instability of the foundations of seafloor structures, destruction of the production well and the drilling installation (Brown et al 2006;Horozal et al 2017;Lu et al 2017;Jin et al 2019;Kayen et al 1991;Li and He 2011;Nixon and Grozic 2007;Scholz et al 2011;Song et al 2019a;Sultan et al 2004;Sun et al 2018;Xu and Germanovich 2006;Zander et al 2018). Therefore, it is paramount to ascertain the stability of the HBS for safe gas exploitation.…”