This paper investigates the effect of concrete degradation due to alkali-silica reactivity (ASR) and its effect on the performance of vertical concrete casks in the case of a hypothetical tip-over event. ASR is one of the major problems in certain concrete structures exposed to high relative humidity and temperature. Using the first order kinetic model, the mechanical and environmental effects of degradation are modeled for a dry-cask storage structure under the conditions that ASR is completely extended. Following the degradation, a tip-over impact simulation was performed and compared with that of an intact cask in terms of failure modes, damage patterns, stresses, and accelerations. It was seen that concrete crushing and shear banding are major failure modes in the cask with intact concrete, but in the case of the ASR affected cask, the concrete is fully damaged and a longitudinal crack which separates the cask into two parts propagates through the outerpack.