The research on the structural response of explosive vessel is an important basis for the design of explosive vessels. Double-layer cylinder structures are widely used in the design of various explosive vessels. This paper studied the deformation of a steel cylindrical shell under internal explosion and proposes a new method for measuring shell deformation by PDV (photonic Doppler velocimetry). We carried out many spherical explosive experiments and obtained useful results that show displacement of the double-layer cylinders and the explosion time. The above process is a simulated LS-DYNA with a finite element numerical simulation. The vibration period of the outer cylindrical shell and the time for reflection of the stress wave in the outer cylindrical shell were obtained by numerical simulation and PDV measurement, respectively. The results of both can be verified against each other. Through the above research, the structural response of the multilayer cylinders can be obtained, which can provide further help with research of the structural design of multilayer cylinders.