The current study aims to present a swarm-optimized technique for the numerical treatment of dengue fever non-linear model. The model is composed of the coupled nonlinear system comprising the susceptible, infected, and recovered compartments. The system is transformed into an unsupervised single layer feed-forward artificial neural network with a Mexican hat wavelet activation function in the hidden layer. The unknowns of the neural network is optimized with particle swarm optimization as an efficient global search aided by the effective local search technique based on sequential quadratic programming. The presented results are compared with state of art Runge-Kutta method and other modern reported techniques on various performance indicators like absolute error, mean average deviation, global absolute error, global mean average deviation, convergence, and computational complexity. Comprehensive Monte Carlo simulations and their statistical analysis are presented to ensure accuracy, consistency in convergence, and computational complexity in terms of execution time. It is observed that the proposed scheme is accurate, reliable, convergent, and computationally viable in treating the nonlinear coupled system under consideration.