The investigation on the flow field and mixing characteristics of resonant sound mixing is of great significance for the dispersion mixing of superfine materials. In order to simulate the flow field and dispersion characteristics of resonant acoustic mixing, a gas-liquid-solid three-phase flow model based on the coupled level-set and volume-of-fluid (CLSVOF) and discrete particle model (DPM) was established. The CLSVOF model solves the gas-liquid interface, and the DPM model tracks the particle position. Then, the particle image velocimetry (PIV) experiment was performed using a self-made resonance acoustic hybrid prototype under different oscillation accelerations, and the radial velocity distribution between the experiment and simulation was compared. Finally, the proper orthogonal decomposition (POD) is used to decompose the flow field under different oscillation accelerations and fill levels, and the energy distribution law and the energy structure of different scales are extracted. The results show that the energy of the instantaneous flow field of the resonant sound is mainly concentrated in the low-order mode, and a close relationship was revealed between the energy distribution law and dispersion behavior of particles. The larger the small-scale coherent structures distribute, the more energy it has and the more favorable it is for fast and uniform dispersion.