Numerical study of interactive motion of dielectrophoretic particles

Xie, Chuanchuan; Chen, Bo; Ng, Chiu‐On; Zhou, Xinping; Wu, Jing

doi:10.1016/j.euromechflu.2014.08.007

Cited by 30 publications

(25 citation statements)

References 16 publications

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“…Among the three approaches, the simplified approach can provide a quick estimation on the force, although the value could be overestimated. The EDM approach yields a lower force estimation than the MST approach, which is consistent with the findings in [48]. The reason could be due to the approximation in the EDM approach, which neglects higher order terms in the computation.…”

Section: Resultssupporting

confidence: 87%

Characterization of biomechanical properties of cells through dielectrophoresis-based cell stretching and actin cytoskeleton modeling

et al. 2017

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BackgroundCytoskeleton is a highly dynamic network that helps to maintain the rigidity of a cell, and the mechanical properties of a cell are closely related to many cellular functions. This paper presents a new method to probe and characterize cell mechanical properties through dielectrophoresis (DEP)-based cell stretching manipulation and actin cytoskeleton modeling.MethodsLeukemia NB4 cells were used as cell line, and changes in their biological properties were examined after chemotherapy treatment with doxorubicin (DOX). DEP-integrated microfluidic chip was utilized as a low-cost and efficient tool to study the deformability of cells. DEP forces used in cell stretching were first evaluated through computer simulation, and the results were compared with modeling equations and with the results of optical stretching (OT) experiments. Structural parameters were then extracted by fitting the experimental data into the actin cytoskeleton model, and the underlying mechanical properties of the cells were subsequently characterized.ResultsThe DEP forces generated under different voltage inputs were calculated and the results from different approaches demonstrate good approximations to the force estimation. Both DEP and OT stretching experiments confirmed that DOX-treated NB4 cells were stiffer than the untreated cells. The structural parameters extracted from the model and the confocal images indicated significant change in actin network after DOX treatment.ConclusionThe proposed DEP method combined with actin cytoskeleton modeling is a simple engineering tool to characterize the mechanical properties of cells.

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Section: Resultssupporting

confidence: 87%

Characterization of biomechanical properties of cells through dielectrophoresis-based cell stretching and actin cytoskeleton modeling

et al. 2017

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“…A recent review [13], categorizes some of the most widely used numerical approaches applied to achieve this goal. These numerical methods can be divided into two distinct categories, those that are capable of solving electric field and/or flow field while taking the particle into account [14,18,[20][21][22], and those that solve electric and flow field independently of the particle, and then apply equivalent forces to the particles based on their location [13,23,24].…”

Section: Introductionmentioning

confidence: 99%

Dynamic drag force based on iterative density mapping: A new numerical tool for three‐dimensional analysis of particle trajectories in a dielectrophoretic system

et al. 2016

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Dielectrophoresis is a widely used means of manipulating suspended particles within microfluidic systems. In order to efficiently design such systems for a desired application, various numerical methods exist that enable particle trajectory plotting in two or three dimensions based on the interplay of hydrodynamic and dielectrophoretic forces. While various models are described in the literature, few are capable of modeling interactions between particles as well as their surrounding environment as these interactions are complex, multifaceted, and computationally expensive to the point of being prohibitive when considering a large number of particles. In this paper, we present a numerical model designed to enable spatial analysis of the physical effects exerted upon particles within microfluidic systems employing dielectrophoresis. The model presents a means of approximating the effects of the presence of large numbers of particles through dynamically adjusting hydrodynamic drag force based on particle density, thereby introducing a measure of emulated particle-particle and particle-liquid interactions. This model is referred to as "dynamic drag force based on iterative density mapping." The resultant numerical model is used to simulate and predict particle trajectory and velocity profiles within a microfluidic system incorporating curved dielectrophoretic microelectrodes. The simulated data are compared favorably with experimental data gathered using microparticle image velocimetry, and is contrasted against simulated data generated using traditional "effective moment Stokes-drag method," showing more accurate particle velocity profiles for areas of high particle density.

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“…When an electrically neutral NW is subjected to a non-uniform electric field, the electric charges redistribution within the NW as well as in the solid-liquid interface builds up an electric dipole moment [32]. Thus, as the Coulomb forces on either sides of the dipole can differ in direction and intensity, a net force is exerted on the NW, which is known as the dielectrophoretic force [19,[27][28][29][30][31][32]. The force direction depends on the relative polarizabilities of the electrolyte and of the NW, inducing the latter move towards or against the region of higher electric field intensity.…”

Section: Introductionmentioning

confidence: 99%

“…The force direction depends on the relative polarizabilities of the electrolyte and of the NW, inducing the latter move towards or against the region of higher electric field intensity. Such motion of nanoparticles is termed as dielectrophoresis (DEP) [19,20,[26][27][28][29][30][31][32]. DEP has a tremendous advantage over the aforementioned techniques, as it relies on the possibility of working with NWs of a wide range of conductivities as well as arbitrary substrates including those that require low-temperature processing such as flexible substrates [18].…”

Section: Introductionmentioning

confidence: 99%

“…Alternatively, NWs suspended in a dielectric electrolytic solution can be manipulated through electric fields [1,5,[26][27][28][29][30][31]. When an electrically neutral NW is subjected to a non-uniform electric field, the electric charges redistribution within the NW as well as in the solid-liquid interface builds up an electric dipole moment [32].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrical Manipulation of a Single Nanowire by Dielectrophoresis

Santos¹,

Béron²,

RobertoPirota³

et al. 2017

Nanowires - New Insights

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Nanowires (NWs), due to their unique highly anisotropic characteristics, hold a great promise to be used in wide technological fields, such as building blocks for data storage and memory, advanced scanning probes, and biotechnological applications. In addition, given the high sensitivity to their environment, NWs can be used as sensor for a number of applications. The fabrication and electrical characterization of NW-based devices can be achieved after proper placing of NWs between electrodes, which represents one of the major challenges in this field. The dielectrophoresis (DEP) method can be used to trap electrically neutral NWs by the application of an alternating electric field between a pair of electrodes. Here, we present a systematic study of DEP parameters as well as electrodes geometry for NW deposition. This method presents a suitable protocol for deposition in a useful and coherent fashion of post-growth electrodeposited NWs and further electrical characterization. This can be used for investigation of the fundamental transport properties of individual NWs and fabrication of NW-based devices, such as sensors and field-effect transistors.

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Numerical study of interactive motion of dielectrophoretic particles

Cited by 30 publications

References 16 publications

Characterization of biomechanical properties of cells through dielectrophoresis-based cell stretching and actin cytoskeleton modeling

Characterization of biomechanical properties of cells through dielectrophoresis-based cell stretching and actin cytoskeleton modeling

Dynamic drag force based on iterative density mapping: A new numerical tool for three‐dimensional analysis of particle trajectories in a dielectrophoretic system

Electrical Manipulation of a Single Nanowire by Dielectrophoresis

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