Direct numerical simulations (DNS) of hypersonic turbulent boundary layers and their freestream acoustic radiation are conducted with a recycling-rescaling (RR) based or a digital-filter (DF) based turbulent inflow generation methodologies. The flow conditions of the simulations falls within the range of nozzle exit conditions of the Purdue Mach 6 Quiet Tunnel. The study provides a first ever comparison between two distinct turbulent inflow generation methodologies at a common hypersonic condition, in terms of both the turbulence statistics within the boundary layer and the acoustic pressure statistics in the free stream. The study shows that simulation results compare well downstream of the adjustment region between the RR-based and the DF-based methodologies.Nomenclature C p heat capacity at constant pressure, J/(K·kg) C v heat capacity at constant volume, J/(K·kg) H shape factor, H = δ * /θ, dimensionless L sRescaling length (i.e. the length between the inlet plane and the recycling station) M Mach number, dimensionless P r Prandtl number, P r = 0.71, dimensionless R ideal gas constant, R = 287, J/(K·kg) Re θ Reynolds number based on momentum thickness and freestream viscosity, Re θ ≡ ρ∞U∞θ µ∞ , dimensionless Re δ2 Reynolds number based on momentum thickness and wall viscosity, Re δ2 ≡ ρ∞U∞θ µw , dimensionless Re τ Reynolds number based on shear velocity and wall viscosity, Re τ ≡ ρwuτ δ µw , dimensionless rms root mean square T temperature, K T r recovery temperature, T r = T ∞ (1 + 0.9 * γ−1 2 M 2 ∞ ), K U ∞ freestream velocity, m/s a speed of sound, m/s p pressure, Pa u streamwise velocity, m/s u τ friction velocity, m/s v spanwise velocity, m/s w wall-normal velocity, m/s x streamwise direction of the right-hand Cartesian coordinate y spanwise direction of the right-hand Cartesian coordinate z wall-normal direction of the right-hand Cartesian coordinate z τ viscous length, z τ = ν w /u τ , m γ specific heat ratio, γ