To gain a comprehensive understanding of the energy dissipation of a double-suction pump, analysing the energy loss of its various components is necessary. However, the liquid temperature in the double-suction pump remains almost constant, using the entropy production or dissipation method to evaluate energy loss is difficult. The traditional analysis method based on pressure drop cannot quantify the internal energy changes in each component. To solve this problem, a pressure energy loss evaluation approach is developed on the basis of the pressure drop theoretical analysis and numerical prediction, and the effects of cavitation on the energy loss are investigated. The structure of the volute casing is improved to enhance the performance based on energy loss analysis and cavitation behaviour prediction. The results show that the energy loss efficiencies for the suction casing, impeller, and volute casing are 0.55, 4.6, and 5%, respectively, at the design flow rate. The proportion of energy loss in the impeller and volute casing increased with a decrease in NPSHa. The RNG k–ε and k–ω turbulence models are chosen for the numerical simulation, and the numerically predicted results are verified experimentally.