Similar to other fluids (Newtonian and non-Newtonian), micropolar fluid also exhibits symmetric flow and exact symmetric solution similar to the Navier–Stokes equation; however, it is not always realizable. In this article, the Buongiorno mathematical model of hydromagnetic micropolar nanofluid is considered. A joint phenomenon of heat and mass transfer is studied in this work. This model indeed incorporates two important effects, namely, the Brownian motion and the thermophoretic. In addition, the effects of magnetohydrodynamic (MHD) and chemical reaction are considered. The fluid is taken over a slanted, stretching surface making an inclination with the vertical one. Suitable similarity transformations are applied to develop a nonlinear transformed model in terms of ODEs (ordinary differential equations). For the numerical simulations, an efficient, stable, and reliable scheme of Keller-box is applied to the transformed model. More exactly, the governing system of equations is written in the first order system and then arranged in the forms of a matrix system using the block-tridiagonal factorization. These numerical simulations are then arranged in graphs for various parameters of interest. The physical quantities including skin friction, Nusselt number, and Sherwood number along with different effects involved in the governing equations are also justified through graphs. The consequences reveal that concentration profile increases by increasing chemical reaction parameters. In addition, the Nusselt number and Sherwood number decreases by decreasing the inclination.