The DNS of film boiling requires strong computational resources that are difficult to obtain for daily CFD use by expert practitioners of industrial R&D. On the other hand, film boiling experiments are associated with the usage of expensive and highly sophisticated apparatus, and research to this end is relatively difficult due to high heat flow rates that are present in the process itself. When combined with transient heat conduction in a solid, the problem becomes significantly difficult. Therefore, a novel method in computation of conjugate heat transfer during film boiling in a quiescent liquid is proposed in this paper. The method relies on the solution of mass, momentum and energy conservation equations in a two-fluid framework, supplemented with the appropriate closures. Furthermore, turbulent flow was determined as an important parameter in obtaining an accurate solution to temperature field evolution in a solid specimen, via the proper modeling of the turbulent kinetic energy (TKE) value, that was imposed as a constant value, i.e., the frozen turbulence approach. It was found, in addition, that the appropriate TKE value can be obtained by use of Kelvin–Helmholtz instability theory in conjunction with boundary layer theory. The obtained results show excellent agreement with the experimental data within the first 15 s of the experiment, i.e., the first ca. 10% of the total duration of the film boiling mode of heat transfer. Furthermore, the heat transfer coefficient matched the error bands prescribed by the authors of this paper, which presented the correlations, whilst the averaged values are far beyond this band, i.e., are slightly more than 30% higher. Further inspection revealed a measure of similarity between the computational result of the volume fraction field distribution and the experiment, thus confirming the capability of the method to obtain realistic interface evolution in time. The method shows full capability for further pursuing industrial-scale film boiling problems that involve turbulent flow and the conjugate heat transfer approach.