In order to explore the critical charge diameter for explosive separation of titanium alloy plates under the structure of double-hole charge. In this paper, based on the SPH algorithm in the AUTODYN software, a numerical model of the explosion separation of titanium alloy plates was established, and numerical simulations were carried out for different charge aperture models.According to the strength criterion and the simulation calculation results, the fracture judgment was carried out, and the fracture mechanism of the double opening separation was analyzed, and the law of the damage to the plate by the diameter of the charging hole was explored. According to the simulation results, the results show that the test results are highly consistent with the simulation results. When the double hole charge structure is used for explosive separation, the size of the charge aperture not only directly affects the effect of explosive separation, but also affects the flying off kinetic energy after plate fracture. Under the influence of various factors, the plate breaks from the hole wall from inside to outside, and finally breaks into a seam to complete the separation. With the increase of the charge hole diameter, the damage condition of the titanium alloy plate increases almost linearly, that is, the larger the charge hole diameter, the more serious the damage to the titanium alloy plate.