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Background: Virus is a tiny agent, around one-hundredth the size of a bacterium which can infect cells of plants and animals. Seven coronaviruses are known to infect humans, three of them are serious, namely, SARS (severe acute respiratory syndrome, China, 2002), MERS (Middle East respiratory syndrome, Saudi Arabia, 2012), and SARS-CoV-2 (COVID-19) (2019-2020).SARS-CoV, and MERS-CoV belong to betacoronaviruses (betaCoVs). Objective: In this mini review, we want to consider the important vitamin D and C, especially plants containing these two vitamins in fight against COVID-19. Methods: The manuscript includes review articles, randomized control experiments, analytical studies and observations, which have been gathered from different sources such as Google Scholar, Scopus, Science Direct and PubMed. A review of the literature was carried out using the keywords such as vitamin D, vitamin C, COVID-19, influenza, Plant, and Coronaviruses. Results: Various sources of vitamin D for humans are food, dietary supplements and the skin by exposure to 7-dehydrocholesterol to ultraviolet light. There are some new findings on influence vitamin D in prevent and control of influenza and COVID-19. Vitamin D may play roles in preventing influenza and covid-19 by production of large quantities of IL-1 and IL-6, or modulating the production of the interleukins. Conclusion: Vitamin D deficiency is a potential link between respiratory infection and immune evasion, and vitamin D is a pleiotropic factor known to modulate immune response against pathogen.
Background: Virus is a tiny agent, around one-hundredth the size of a bacterium which can infect cells of plants and animals. Seven coronaviruses are known to infect humans, three of them are serious, namely, SARS (severe acute respiratory syndrome, China, 2002), MERS (Middle East respiratory syndrome, Saudi Arabia, 2012), and SARS-CoV-2 (COVID-19) (2019-2020).SARS-CoV, and MERS-CoV belong to betacoronaviruses (betaCoVs). Objective: In this mini review, we want to consider the important vitamin D and C, especially plants containing these two vitamins in fight against COVID-19. Methods: The manuscript includes review articles, randomized control experiments, analytical studies and observations, which have been gathered from different sources such as Google Scholar, Scopus, Science Direct and PubMed. A review of the literature was carried out using the keywords such as vitamin D, vitamin C, COVID-19, influenza, Plant, and Coronaviruses. Results: Various sources of vitamin D for humans are food, dietary supplements and the skin by exposure to 7-dehydrocholesterol to ultraviolet light. There are some new findings on influence vitamin D in prevent and control of influenza and COVID-19. Vitamin D may play roles in preventing influenza and covid-19 by production of large quantities of IL-1 and IL-6, or modulating the production of the interleukins. Conclusion: Vitamin D deficiency is a potential link between respiratory infection and immune evasion, and vitamin D is a pleiotropic factor known to modulate immune response against pathogen.
Background and Objectives: Despite frequent references to the high prevalence of vitamin D deficiency in Kazakhstan, a comprehensive synthesis of existing research on this issue among adults is lacking. This systematic review and meta-analysis aim to address this gap by determining the mean prevalence of vitamin D deficiency among adults in Kazakhstan. A secondary objective is to evaluate whether the prevalence differs between healthy adults and those with chronic conditions. Materials and Methods: A systematic search was conducted in PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar by two independent researchers using the keywords: “vitamin D” AND “Kazakhstan”, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were included if they reported the prevalence of vitamin D in adults in Kazakhstan, defined as a blood level of 25-hydroxyvitamin D 25(OH)D below 20 ng/mL. Results: Seven studies were included in this review, encompassing 3616 individuals, of whom 2239 had vitamin D deficiency. Using a random-effects model, the pooled mean prevalence of vitamin D deficiency among adults with chronic conditions was 60% (95% CI, 38–79%), with high heterogeneity. Similarly, the analysis of five studies involving healthy adults revealed a pooled mean prevalence of 55% (95% CI, 38–70%), also with high heterogeneity. Overall, the pooled mean prevalence of vitamin D deficiency in the adult population was 57% (95% CI, 45–69%). Conclusions: This analysis indicates a high prevalence of vitamin D deficiency among adults in Kazakhstan, with 57% of the population affected. Addressing this issue requires a multifaceted approach, including policy reforms that consider the impact of time zone changes on sunlight exposure and the active involvement of nurse practitioners in preventive strategies.
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