Nurses represent a high percentage of employees in health care; however, there is a shortage. Working as a nurse includes both advantages, such as job security, and disadvantages, such as a greater risk of developing mental ill health. Aim: To explore which salutogenic and pathogenic factors influence nurses’ health and work situation. Methodology: In-depth interviews with nurses who worked during the COVID-19 pandemic. Snowball sampling and deductive content analysis were performed. Findings: When conditions were lacking in providing good care, there was a feeling of betrayal and anger toward the organizations. Moreover, collegial support was crucial for mental health, and some nurses experienced flourishing. Conclusion: Healthcare professionals in Sweden face several challenges, including undersized organizations and the need for primary care expansion to reduce hospital burdens. A better balance of resources (equipment, funding, staff) is essential for nurses to perform effectively. Strong colleague support enhances interprofessional collaboration, but organizational prerequisites are crucial. Improved working conditions and organizational support help retain nurses. Identifying factors for a sustainable working life involves understanding nine key areas and their interactions. Healthcare organizations and managers should consider these areas to promote sustainability. To ensure a competent supply, we must rethink the resources we have by using new working methods, digitization, the transfer of tasks to primary care, etc. Nurses must advocate for equitable systems, fair compensation, and safe environments.