(1) Background: The nurse structure is the largest proportion of the healthcare team in hospitals and Primary Healthcare Centers (PHCs). Empowerment is considered a vital component in strategic planning implementation and plays an important role in enhancing job commitment, motivation and employee satisfaction. (2) Aim: The aim of this study is to examine the relationship between the empowerment and organizational commitment from a nurse’s perspective in the MOH in Makkah city in Saudi Arabia. (3) Methods: A descriptive, correlational design was utilized. The study was conducted at three hospitals affiliated with the Ministry of Health in Makkah. A random stratified sampling of 318 nurses voluntarily participated. Data were collected using two tools; Conditions for Workplace Effectiveness Questionnaire-II (CWEQ-II) to measure nurses’ empowerment, and the Organizational Commitment Questionnaire (OCQ). (4) Results: This study revealed that the nurses in Makkah city have a moderate degree of empowerment. Moreover, the level of organizational commitment among nurses was moderate. In addition, this study showed that there is a significant positive relationship between nurses’ empowerment and their organizational commitment. (5) Conclusion: By conducting this study, it seems that nurse’s empowerment is considered an important healthcare organizational strategy and nurses feel empowered by several factors, such as having access to power through informal and formal means and having access to organizational opportunity, access to support, access to information and access to resources. Access to sources of empowerment influences a nurse’s organizational commitment.